Ruprecht-Karls-Universität Heidelberg
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Bruegger0219 - Scientist (f/m) / PhD position
Project no:
Bruegger0219

Project leader:

Project supervisor:
Brügger, Britta
Application deadline:
31. Jul 2019
Start of PhD project:
1. Sep 2019

Project description:

Title:
Membrane lipids and proteins in Influenza replication and spread
Summary:
Type A influenza viruses (IAV) are the main cause of influenza, a severe respiratory illness. IAV buds from the apical surface of polarized epithelial cells, and the viral membrane has a raft-like lipid composition. Several host factors, including proteins and membrane sphingolipids, have been implicated in supporting and restricting IAV infection, but their mechanisms of action are only partly known. Within the frame of the SFB1129 we aim to gain a better understanding on protein-lipid interactions in IAV replication and spread. This project combines chemical biology/biochemistry, lipidomics and cell biology methods and will include both in vitro and cellular experiments. The project is performed in collaboration with the groups of Hans-Georg Kräusslich (Virology, Heidelberg) and Petr Chlanda who provide expertise in virology and super-resolution/cryo-electron microscopy.
References:
https://www.bzh.uni-heidelberg.de/bruegger
Methods that will be used:
Chemical biology approaches, biochemistry, cell biology, virology, lipidomics
Cooperation partners:
Collaborations within SFB1129
Personal qualifications:
We are looking for enthusiastic students with a master degree in the Life Sciences with practical experience in virology, chemical biology, biochemistry and/or cell biology.
Keywords:
Protein-lipid interactions, IAV, lipidomics, host restriction factors, sphingolipid homeostasis