Ruprecht-Karls-Universität Heidelberg
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Boutros, Michael, Prof. Dr. (Project leader)
German Cancer Research Center (DKFZ)
Complete address:
German Cancer Research Center (DKFZ)
Division Signaling and Functional Genomics
Im Neuenheimer Feld 580
D-69120 Heidelberg
+49 6221-42 1951
+49 6221-42 1959

Fields of interest:

Functional genomics, systems biology, signaling during development and cancer, genomic approaches to dissect signaling pathways
Signaling, Development, Genome biology, Cancer research

Curriculum Vitae:

Full professor, Heidelberg University

Head of Division, German Cancer Research Center

Emmy-Noether Group, German Cancer Research Center

Postdoctoral Fellow, Harvard Medical School, USA

Kennedy School of Government, MPA Program, Harvard University, USA

Ph.D. Program, European Molecular Biology Laboratory

Selected publications:

Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping. (2013) Laufer C, Fischer B, Billmann M, Huber W and Boutros M Nature Methods 10, 427–431.

Active Wnt proteins are secreted on exosomes. (2012) Gross JC, Chaudhary V, Bartscherer K and Boutros M Nat Cell Biol 14, 1036–1045

Mapping of signaling networks through synthetic genetic interacton analysis by RNAi (2011) Horn T, Sandmann T, Fischer B, Axelsson E, Huber W, Boutros M Nature Methods, in press

Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor (2010) Buechling T, Bartscherer K, Ohkawara B, Chaudhary V, Spirohn K, Niehrs C, Boutros M Current Biology 20:1263-1268

Clustering phenotype populations by genome-wide RNAi and multiparametric imaging (2010) Fuchs F, Pau G, Kranz D, Sklyar O, Budjan C, Steinbrink S, Horn T, Pedal A, Huber W, Boutros M Molecular Systems Biology 6:370.

Requirement of prorenin receptor an vacuolar H+-ATPase-mediated acidification for Wnt signaling (2010) Cruciat CM, Ohkawara B, Acebron SP, Karaulanov E, Reinhard C, Ingelfinger D, Boutros M, Niehrs C Science 327:459-63.

Secretion of Wnt ligands require Evi, a conserved transmembrane protein. (2006) Bartscherer K, Pelte N, Ingelfinger D, Boutros M Cell 125:523-533.

Identification of JAK/STAT signaling components by genome-wide RNAi. (2005) Muller P, Kuttenkeuler D, Gesellchen V, Zeidler M, Boutros M Nature, 436:871-5.

Genome-wide RNAi Analysis of Cell Growth and Viability in Drosophila. (2004) Boutros M, Kiger AA, Armknecht S, Kerr K, Hild M, Koch B, Haas S, Paro R and Perrimon N Science 303:832-5.

Signaling specificity by Frizzled receptors in Drosophila (2000) Boutros M, Mihaly J, Bouwmeester T, Mlodzik M Science 288: 1825-1828

Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signalling (1998) Boutros M, Paricio N, Strutt D, Mlodzik M Cell 94: 109-118