Ruprecht-Karls-Universität Heidelberg
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Brunner, Michael, Prof. Dr. (Project leader)
Biochemistry Center Heidelberg (BZH)
Complete address:
Biochemistry Center (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg
+49 6221-54 4207
+49 6221-54 4769

Fields of interest:

Circadian rhythm and molecular clock of Neurospora crassa and in mammalian cell culture; gene regulation by light and temperature.

Curriculum Vitae:

Professor (C4) Heidelberg University Biochemistry Center

Professor (C3) Ludwig-Maximilians-University (LMU), Munich

Habilitation (Medical Faculty) LMU, Munich

Group leader at the Institute of Physiological Chemistry LMU, Munich

Post doctoral fellow, Princeton University and Sloan-Kettering Institute, New York

PhD, ZMBH and Hoffman LaRoche, Basel

Biology Diploma, Heidelberg University

Selected publications:

MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation. (2016) Shostak A, Ruppert B, Ha N, Bruns P, Toprak UH; ICGC MMML-Seq Project, Eils R, Schlesner M, Diernfellner A, Brunner M Nat Commun. 2016 Jun 24;7:11807. doi: 10.1038/ncomms11807.

MYC inhibits the clock and supports proliferation. (2016) Shostak A, Diernfellner A, Brunner M Cell Cycle. 2016 Sep 7:1-2.

Dawn- and dusk-phased circadian transcription rhythms coordinate anabolic and catabolic functions in Neurospora. (2015) Sancar C, Sancar G, Ha N, Cesbron F, Brunner M BMC Biol. Feb 24;13(1):17

Transcriptional refractoriness is dependent on core promoter architecture. (2015) Cesbron F, Oehler M, Ha N, Sancar G, Brunner M Nat Commun. 6:6753. doi: 10.1038/ncomms7753

Combinatorial control of light induced chromatin remodeling and gene activation in Neurospora. (2015) Sancar C, Ha N, Yilmaz R, Tesorero R, Fisher T, Brunner M, Sancar G PLoS Genet. 11(3):e1005105. doi: 10.1371/journal.pgen.1005105

Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis. (2015) Zhai Z, Kondo S, Ha N, Boquete JP, Brunner M, Ueda R, Lemaitre B Nat Commun Dec 22;6:10219. doi: 10.1038/ncomms 10219.

Circadian clocks and energy metabolism. (2014) Sancar G, Brunner M Cell Mol Life Sci 71: 2667-2680

Alteration of light-dependent gene regulation by the absence of the RCO-1/RCM-1 repressor complex in the fungus Neurospora crassa. (2014) Ruger-Herreros C, Gil-Sanchez Mdel M, Sancar G, Brunner M, Corrochano LM PLoS One 9: e95069

Light-induced differences in conformational dynamics of the circadian clock regulator VIVID. (2014) Lee CT, Malzahn E, Brunner M, Mayer MP J Mol Biol 426: 601-610

The RNA helicase FRH is an ATP-dependent regulator of CK1a in the circadian clock of Neurospora crassa. (2014) Lauinger L, Diernfellner A, Falk S, Brunner M Nat Commun 5: 3598

Non-circadian expression masking clock-driven weak transcription rhythms in U2OS cells. (2014) Hoffmann J, Symul L, Shostak A, Fischer T, Naef F, Brunner M PLoS One 9: e102238

The Neurospora photoreceptor VIVID exerts negative and positive control on light sensing to achieve adaptation. (2013) Gin E., Diernfellner A.C.R., Brunner, M., Höfer T. Mol Syst Biol. 28:9, 667.

O-GlcNAcylation of a circadian clock protein: dPER taking its sweet time. (2012) Diernfellner, A.C.R. and Brunner, M. Genes Dev 226, 415-416.

Glycogen Synthase Kinase is a regulator of the circadian clock of Neurospora crassa. (2012) Tataroglu O., Lauinger L., Sancar G., Jakob K., Brunner M., Diernfellner A.C. J Biol Chem 287, 36936-36943.

Metabolic compensation of the Neurospora clock by a glucose-dependent feedback of the circadian repressor CSP1 on the core oscillator. (2012) Sancar, G., Sancar, C. and Brunner, M. Genes Dev 26, 2435-2442.

Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control
circadian output functions in mouse liver.
(2011) Rey, G., Cesbron, F., Rougemont, J., Reinke, H., Brunner, M. and Naef, F. PLoS Biol. 9:e1000595.

A global circadian repressor controls anti-phasic expression of metabolic genes in Neurospora. (2011) Sancar, G., Sancar C., Brügger, B., Ha, N. Sachsenheimer, T., Gin, E., Wdowik, S., Lohmann, I., Wieland, F., Hoefer, T., Diernfellner, A. and Brunner, M. Mol. Cell 44, 687-697.

Circadian conformational change of the Neurospora clock protein FREQUENCY triggered by clustered hyperphosphorylation of a basic domain. (2011) Querfurth, C., Diernfellner, A.C.R., Gin, E., Höfer, T. and Brunner M. Mol Cell 43, 713-722.

Special Issue: Circadian Rhythms. (2011) Merrow M. and Brunner M. (eds.) FEBS Lett 585.

Transcription factors in light and circadian clock signaling networks revealed by genome-wide mapping of direct targets for neurospora white collar complex. Eukaryot Cell 9, 1549-1556. (2010) Smith, K.M., Sancar, G., Dekhang, R., Sullivan, C.M., Li, S., Tag, A.G., Sancar, C., Bredeweg, E.L., Priest, H.D., Mccormick, R.F., Thomas, T.L., Carrington J.C., Stajich, J.E., Bell-Pedersen, D., Brunner, M. and Freitag, M. Eukaryot Cell 9, 1549-1556.

Photoadaptation in Neurospora by competitive interaction of activating and inhibitory LOV domains (2010) Malzahn E, Ciprianidis S, Kaldi K, Schafmeier T, Brunner M Cell 142: 762-772

Phosphorylation modulates rapid nucleo-cytoplasmic shuttling and cytoplasmic accumulation of Neurospora clock protein FRQ on a circadian time scale. (2009) Diernfellner, A., Querfurth, C., Salazar, C., Höfer, T., Brunner, M. Genes Dev 23, 2192-2200

Circadian activity and abundance rhythms of the Neurospora clock transcription
factor WCC associated with rapid nucleo-cytoplasmic shuttling.
(2008) Schafmeier T, Diernfellner A, Schäfer A, Dintsis O, Neiss A, Brunner M.
Genes Dev. 22(24):3397-402.

Circadian activity and abundance rhythms of the Neurospora clock transcription factor WCC associated with rapid nucleo-cytoplasmic shuttling (2008) Schafmeier T, Diernfellner A, Schafer A, Dintsis O, Neiss A, Brunner M Genes Dev 22: 3397-3402

Phosphorylation-dependent maturation of Neurospora circadian clock protein from a nuclear repressor toward a cytoplasmic activator (2006) Schafmeier T, Kaldi K, Diernfellner A, Mohr C, Brunner M Genes Dev 20: 297-306

Molecular mechanism of temperature sensing by the circadian clock of Neurospora crassa (2005) Diernfellner AC, Schafmeier T, Merrow MW, Brunner M Genes Dev 19: 1968-1973

Transcriptional feedback of Neurospora circadian clock gene by phosphorylation-dependent inactivation of its transcription factor (2005) Schafmeier T, Haase A, Kaldi K, Scholz J, Fuchs M, Brunner M Cell 122: 235-246

Tim23 links the inner and outer mitochondrial membranes (2000) Donzeau M, Kaldi K, Adam A, Paschen S, Wanner G, Guiard B, Bauer MF, Neupert W, Brunner M Cell 101: 401-412

Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5 (1998) Sirrenberg C, Endres M, Folsch H, Stuart RA, Neupert W, Brunner M Nature 391: 912-915

Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria (1996) Bauer MF, Sirrenberg C, Neupert W, Brunner M Cell 87: 33-41

Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22. (1996) Sirrenberg C, Bauer MF, Guiard B, Neupert W, Brunner M Nature 384: 582-585

Light-dependent and circadian transcription dynamics in vivo recorded with a destabilized luciferase reporter in Neurospora. (1990) Cesbron F., Brunner M., Diernfellner A.C.R. PLoS One 8 (12), e83660.