Ruprecht-Karls-Universität Heidelberg
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Bading, Hilmar, Prof. Dr. (Project leader)
Interdisciplinary Center for Neurosciences (IZN)
Complete address:
Neurobiology Institute
Interdisciplinary Center for Neurosciences (IZN)
Im Neuenheimer Feld 364
69120 Heidelberg
+49 6221 54 8218
+49 6221 54 6700

Fields of interest:

Neuronal signaling, nuclear calcium, gene regulation, neuronal plasticity, activity-dependent survival.

Curriculum Vitae:

Professor (C4) of Neurobiology, Director Neurobiology Institute, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University

Group Leader at the MRC Laboratory of Molecular Biology, Cambridge, England

Harvard Medical School, Boston, USA, post-doctoral research in the Department of Microbiology and Molecular Genetics, Prof. Michael E. Greenberg

Max Planck Institut für molekulare Genetik, Berlin, post-doctoral research

MD (Dr. med.)

Max Planck Institut für medizinische Forschung, Heidelberg

Heidelberg University (Humanmedizin)

Selected publications:

Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity. (2009) Zhang SJ, Zou M, Lu L, Lau D, Ditzel DA, Delucinge-Vivier C, Aso Y, Descombes P, Bading H. PLoS Genet. Aug;5(8):e1000604.

Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death. (2007) Zhang, SJ, Steijaert, MN, Lau, D, Schütz, G, Delucinge-Vivier, C, Descombes, P, and Bading, H Neuron 53, 549-562.

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways (2002) Hardingham GE, Fukunaga Y, Bading H Nat Neurosci 5: 405-414

A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication (2001) Hardingham GE, Arnold FJ, Bading H Nat Neurosci 4: 565-566

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity (2001) Hardingham GE, Arnold FJ, Bading H Nat Neurosci 4: 261-267

Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels (1999) Hardingham GE, Chawla S, Cruzalegui FH, Bading H Neuron 22: 789-798

CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV (1998) Chawla S, Hardingham GE, Quinn DR, Bading H Science 281: 1505-1509

Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression (1997) Hardingham GE, Chawla S, Johnson CM, Bading H Nature 385: 260-265

Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways (1993) Bading H, Ginty DD, Greenberg ME Science 260: 181-186

Stimulation of protein tyrosine phosphorylation by NMDA receptor activation (1991) Bading H, Greenberg ME Science 253: 912-914