Ruprecht-Karls-Universit├Ąt Heidelberg
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Bartenschlager, Ralf, Prof. Dr. (Project leader)
Affiliation:
Department of Infectious Diseases
Complete address:
Department of Infectious Diseases
Im Neuenheimer Feld 345
69120 Heidelberg
Phone:
+49 6221 56 4569
Fax:
+49 6221 56 54570
CV (PDF):

Fields of interest:

Virus-host cell interaction, mechanism of host cell infection, live cell imaging and electron microscopy, virus assembly and involved host cell factors, RNA replication, proteases and polymerases, RNA structures, mathematical modelling of virus replication, transcriptome analysis of virus-induced host cell genes, innate immunity, interferon response and viral counter measures, antiviral therapy and therapy resistance
Keywords:

Curriculum Vitae:

2002 
-
Present 
Full professor and head of department of Molecular Virology, Heidelberg University

2001 
-
 
Full professor for Molecular Virology, University of Mainz

1999 
-
 
Habilitation, University of Mainz

1994 
-
1998 
Assistant, University of Mainz

1992 
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1993 
PostDoc, Central Research Unit, Hoffmann-La Roche AG, Basel

1991 
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PostDoc, Center for Molecular Biology, Heidelberg

1990 
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PhD in Molecular Biology

1981 
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1987 
Studies in Biology (Heidelberg)

Selected publications:

Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment (2011) Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Buhler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Cell Host Microbe 9: 32-45

Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly (2010) Jirasko V, Montserret R, Lee JY, Gouttenoire J, Moradpour D, Penin F, Bartenschlager R PLoS Pathog 6: e1001233

Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. (2009) Kaul A, Stauffer S, Berger C, Pertel T, Schmitt J, Kallis S, Lopez MZ, Lohmann V, Luban J, Bartenschlager R. PLoS Pathog. 5(8):e1000546.

Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations. (2009) Pietschmann T, Zayas M, Meuleman P, Long G, Appel N, Koutsoudakis G, Kallis S, Leroux-Roels G, Lohmann V, Bartenschlager R. PLoS Pathog. 5(6):e1000475.

Composition and three-dimensional architecture of the dengue virus replication and assembly sites. (2009) Welsch S, Miller S, Romero-Brey I, Merz A, Bleck CK, Walther P, Fuller SD, Antony C, Krijnse-Locker J, Bartenschlager R. Cell Host Microbe. 5(4):365-75.

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response (2009) Dazert E, Neumann-Haefelin C, Bressanelli S, Fitzmaurice K, Kort J, Timm J, McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen HR, Shaw J, Bowness P, Blum HE, Klenerman P, Bartenschlager R, Thimme R J Clin Invest 119: 376-386

Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly (2008) Appel N, Zayas M, Miller S, Krijnse-Locker J, Schaller T, Friebe P, Kallis S, Engel U, Bartenschlager R PLoS Pathog 4: e1000035

Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly (2008) Jirasko V, Montserret R, Appel N, Janvier A, Eustachi L, Brohm C, Steinmann E, Pietschmann T, Penin F, Bartenschlager R J Biol Chem 283: 28546-28562

The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner (2007) Miller S, Kastner S, Krijnse-Locker J, Buhler S, Bartenschlager R J Biol Chem 282: 8873-8882

Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus (2007) Steinmann E, Whitfield T, Kallis S, Dwek RA, Zitzmann N, Pietschmann T, Bartenschlager R Hepatology 46: 330-338