Ruprecht-Karls-Universität Heidelberg
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Breuhahn, Kai, PD. Dr. (Project leader)
University Hospital Heidelberg
Complete address:
Institute of Pathology
University Hospital
Im Neuenheimer Feld 220/221
69120 Heidelberg
+49 6221 56 4675
+49 6221 56 5251
Cv.pdf (169 kByte)

Fields of interest:

- liver cancer (hepatocellular carcinoma; HCC) and liver regeneration
- regulation of transcription factors and transcriptional regulators
- oncogenic mechanisms of transcriptional regulators
- migration and proliferation of non small cell lung cancer (NSCLC) cells
- connecting signalling pathways in cancer cells
hepatocellular carcinoma, FBPs, Hippo signalling, migration, stathmin,

Curriculum Vitae:

No cv filled in

Selected publications:

Yes-Associated Protein Upregulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma. (2013) Tschaharganeh DF, Chen X, Latzko P, Malz M, Gaida MM, Felix K, Ladu S, Singer S, Pinna F, Gretz N, Sticht C, Tomasi ML, Delogu S, Evert M, Fan B, Ribback S, Jiang L, Brozzetti S, Bergmann F, Dombrowski F, Schirmacher P, Calvisi DF, Breuhahn K. Gastroenterology. [Epub ahead of print]

A Systems Biology Study on NFκB Signaling in Primary Mouse Hepatocytes. (2012) Pinna F, Sahle S, Beuke K, Bissinger M, Tuncay S, D'Alessandro LA, Gauges R, Raue A, Timmer J, Klingmüller U, Schirmacher P, Kummer U, Breuhahn K. Front Physiol. 3:466.

Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. (2012) Singer S, Zhao R, Barsotti AM, Ouwehand A, Fazollahi M, Coutavas E, Breuhahn K, Neumann O, Longerich T, Pusterla T, Powers MA, Giles KM, Leedman PJ, Hess J, Grunwald D, Bussemaker HJ, Singer RH, Schirmacher P, Prives C. Mol Cell. 14;48(5):799-810.

Nuclear accumulation of seven in absentia homologue-2 supports motility and proliferation of liver cancer cells. (2012) Malz M, Aulmann A, Samarin J, Bissinger M, Longerich T, Schmitt S, Schirmacher P, Breuhahn K. Int J Cancer. 1;131(9):2016-26.

Transcriptional regulators in hepatocarcinogenesis - Key integrators of malignant transformation. (2012) Malz M, Pinna F, Schirmacher P, Breuhahn K. J Hepatol. 57(1):186-95. (Review)

Nuclear expression of the ubiquitin ligase seven in absentia homolog (SIAH)-1 induces proliferation and migration of liver cancer cells. (2011) Brauckhoff A, Malz M, Tschaharganeh D, Malek N, Weber A, Riener MO, Soll C, Samarin J, Bissinger M, Schmidt J, Longerich T, Ehemann V, Schirmacher P, Breuhahn K. J Hepatol. 55(5):1049-57.

Strategies for hepatocellular carcinoma therapy and diagnostics: lessons learned from high throughput and profiling approaches. (2011) Breuhahn K, Gores G, Schirmacher P. Hepatology. 53(6):2112-21. (Review)

The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells. (2010) Kossatz U, Breuhahn K, Wolf B, Hardtke-Wolenski M, Wilkens L, Steinemann D, Singer S, Brass F, Kubicka S, Schlegelberger B, Schirmacher P, Manns MP, Singer JD, Malek NP. J Clin Invest. 120(11):3820-33.

Overexpression of far upstream element binding proteins: A mechanism regulating proliferation and migration in liver cancer cells. (2009) Malz M, Weber A, Singer S, Riehmer V, Bissinger M, Riener MO, Longerich T, Soll C, Vogel A, Angel P, Schirmacher P, Breuhahn K. Hepatology 50(4):1130-9.

Coordinated expression of stathmin family members by far upstream sequence element (FUSE)-binding protein (FBP)-1 increased motility in non-small cell lung cancer. (2009) Singer S, Malz M, Herpel E, Warth A, Bissinger M, Keith M, Muley T, Meister M, Hoffmann H, Penzel R, Gdynia G, Ehemann V, Schnabel PA, Kuner R, Huber P, Schirmacher P, Breuhahn K. Cancer Res. 15;69(6):2234-43.