Ruprecht-Karls-Universität Heidelberg
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Schroten0117 - Scientist (f/m) / PhD position
Project no:
Schroten0117

Project leader:

Project supervisor:
Schroten, Horst
Application deadline:
31. Dec 2017
Start of PhD project:
1. Feb 2018

Project description:

Title:
Pathogenesis of Meningitis caused by Listeria monocytogenes
Summary:
Our group focuses on the pathogenesis of infectious diseases including meningitis caused in the central nervous system (CNS) by bacterial pathogens. Previously, we have studied the transcriptional response of host cells to infection with Listeria monocytogenes using in vitro models of the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) located at the choroid plexus (CP). Still, the cellular molecular machineries and signalling pathways involved are only incompletely understood. The aim of this project is to increase knowledge about the mechanisms of host-pathogen interactions, which participate during meningitis caused by Listeria monocytogenes. We plan to employ in vitro and in vivo models to study the importance of cellular signalling pathways for invasion and transmigration of bacteria as well as for host cell responses
References:
Dinner et al. (2017). Mitogen-activated protein kinases are required for effective infection of human choroid plexus epithelial cells by Listeria monocytogenes. Microbes Infect. 19:18-33

Gründler et al. (2013). The surface proteins InlA and InlB are interdependently required for polar basolateral invasion by Listeria monocytogenes in a human model of the blood-cerebrospinal fluid barrier. Microbes Infect. 15:291-301.

Schwerk et al. (2012) Polar invasion and translocation of Neisseria meningitidis and Streptococcus suis in a novel human model of the blood-cerebrospinal fluid barrier. PLoS One. 7:e30069.
Methods that will be used:
A wide range of molecular and cell biological techniques, transwell filter tissue culture, infection studies with bacterial human pathogens, mouse experiments
Cooperation partners:
Prof. Véronique Orian-Russeau, Institute for Toxicology and Genetics, Karlsruhe Institute of Technology

Prof. Trinad Chakraborty, Institute of Medical Microbiology, German Center for Infection, Justus Liebig University Giessen
Personal qualifications:
We are looking for a highly motivated candidate with interest in basic research who holds a master degree (or equivalent) in molecular biology, biochemistry, cell biology or similar.
Keywords: