Ruprecht-Karls-Universität Heidelberg
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Schroten0217 - Scientist (f/m) / PhD position
Project no:

Project leader:

Project supervisor:
Schroten, Horst
Application deadline:
20. Feb 2018
Start of PhD project:
1. Apr 2018

Project description:

Pathogens modulating the host response by subverting epigenetics
Our group focuses on the pathogenesis of infectious diseases including meningitis caused in the central nervous system (CNS) by bacterial pathogens. Epigenetic mechanisms including DNA methylation, non-coding RNA-mediated gene regulation and histone modification are known to functionally modify the genome without changes in the nucleotide sequence. Pathogens have been shown to subvert the host’s epigenetic and miRNA machinery to modify the host immune response for their own benefit.
In the proposed project the aim will be to analyze the epigenetic and miRNA control of the host immune system during infection.
The project will involve in vitro cell culture assays as well as handling of pathogenic agents. Methods involved might be extended to in vivo analyses.
Schwerk C, Tenenbaum T, Kim KS, Schroten H. The choroid plexus-a multi-role player during infectious diseases of the CNS. Front Cell Neurosci. 2015 Mar 12;9:80

Bierne H, Hamon M, Cossart P. Epigenetics and bacterial infections.
Cold Spring Harb Perspect Med. 2012 Dec 1;2(12):a010272
Methods that will be used:
A wide range of molecular and cell biological techniques, transwell filter tissue culture, infection studies with bacterial human pathogens, possibly mouse experiments
Cooperation partners:
Personal qualifications:
We are looking for a highly motivated candidate with interest in basic research who holds a master degree (or equivalent) in molecular biology, biochemistry, cell biology or similar.