Ruprecht-Karls-Universität Heidelberg
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Schiebel0318 - Scientist (f/m) / PhD position
Project no:
Schiebel0318

Project leader:

Project supervisor:
Schiebel, Elmar
Application deadline:
28. Feb 2018
Start of PhD project:
1. Apr 2018

Project description:

Title:
Centrosome duplication
Summary:
The centrosomes is the main microtubule organizing centre of human cells. As DNA centrosomes duplicate once per cell cycle. Malfunction of centrosome duplication is a hallmark of cancer cells and recent data suggest that centrosome overamplificaiton contributes to cell transformation. In addition, lack of centrosomes or to many centrosomes causes chromosome missegregation and p53 activation leading to cell cycle arrest in G1.

The PhD position is funded for 3 years.

Please send applications to E. Schiebel (schiebel.elmar@zmbh.uni-heidelberg.de).
References:
1 Mardin, B. R., Agircan, F. G., Lange, C. & Schiebel, E. Plk1 Controls the Nek2A-PP1gamma Antagonism in Centrosome Disjunction. Curr Biol 21, 1145-1151, doi:S0960-9822(11)00605-1 [pii]
10.1016/j.cub.2011.05.047 (2011).

2 Mardin, B. R. et al. EGF-induced centrosome separation promotes mitotic progression and cell survival. Dev Cell 25, 229-240, doi:S1534-5807(13)00161-5 [pii]
10.1016/j.devcel.2013.03.012 (2013).

3 Mardin, B. R. et al. Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat Cell Biol 12, 1166-1176, doi:ncb2120 [pii]
10.1038/ncb2120 (2010).

4 Mardin, B. R. & Schiebel, E. Breaking the ties that bind: New advances in centrosome biology. J Cell Biol 197, 11-18, doi:jcb.201108006 [pii]
10.1083/jcb.201108006 (2012).

5 Rüthnick, D. & Schiebel, E. Duplication of the yeast spindle pole body once per cell cycle. Mol Cell Biol 36, 1324-1331, doi:10.1128/MCB.00048-16 (2016).
Methods that will be used:
In this project we will study cell cycle dependent centrosome duplication and steps leading to centrosome maturation in G2 and mitosis. The PhD student will use biochemical approaches, super resolution microscopy (STED), electron microscopy, CRISPR/Cas9 technology and live cell imaging to study centrosome duplication in untransformed and cancer cells.
Cooperation partners:
Personal qualifications:
Highly motivated PhD students with a background in biochemistry, cell biology or molecular biology should apply. Successful candidates will be part of an international team of PhD students and postdocs that works at the forefront of scientific research.
Keywords: