Ruprecht-Karls-Universität Heidelberg
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MuellerU0118 - Scientist (f/m) / PhD position
Project no:
MuellerU0118

Project leader:

Project supervisor:
Müller, Ulrike
Application deadline:
31. May 2018
Start of PhD project:
1. Jul 2018

Project description:

Title:
Functions of the Amyloid precursor protein gene family
Summary:
We are interested in the physiological and pathological functions of the amyloid precursor protein APP gene family. APP is not only central to the pathogenesis of Alzheimer´s disease, but is also involved in synaptogenesis and synaptic plasticity. The successful applicant will study the synaptic roles of the APP gene family and their processing products. Techniques employed include state of the art molecular biology, biochemistry, imaging and work with genetically modified mouse mutants (gain and loss of function studies) and viral vectors.
References:
Müller et al., Nature Rev Neuroscience 18, 28, 2017
Fol et al., Acta Neuropathologica 131, 247, 2016
Richter et al., EMBO J. early online https://doi.org/10.15252/embj.201798335
Methods that will be used:
See above, also involves animal experimentation
Cooperation partners:
Prof. Martin Korte Göttingen (electrophysiology)
Personal qualifications:
The ideal candidate is highly motivated, open minded and holds a MSc in a relevant discipline of life science (e.g. Molecular Biology, Biochemistry, Cell Biology, Neuroscience, etc). We expect a solid background in neurobiology, molecular biology and cell biology. Experience with tissue culture and genetically modified mouse models would be a plus. We expect the successful candidate to participate in animal experimentation.
Keywords:
Alzheimer, Amyloid precursor protein, knockout, synaptic plasticity