Ruprecht-Karls-Universit├Ąt Heidelberg
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Bischofs0118 - Scientist (f/m) / PhD position
Project no:
Bischofs0118

Project leader:

Project supervisor:
Bischofs, Ilka
Application deadline:
31. Jul 2018
Start of PhD project:
1. Sep 2018

Project description:

Title:
Quantitative phenotyping of bacterial spore traits by high-resolution microscopy
Summary:
Our lab studies complex adaptive traits (CATs) in bacteria with the goal to understand, to control and to engineer such traits. In response to fluctuations in nutrient availability, many bacterial species adapt by switching between a proliferative vegetative and a dormant endospore state. Common to both processes is a striking degree of phenotypic heterogeneity. Due to the significance of this phenomenon for both fundamental and applied research, we aim to elucidate its underlying mechanisms and to study how this contributes to the organization of the population in fluctuating environments. This project specifically aims to establish a high-throughput workflow for quantitative spore phenotyping based on fluorescence time-lapse microscopy and SEM array tomography in order to identify and validate determinants of traits of interest on the molecular and structural level.
References:
Mutlu et al., Nature Communications 9:69, 2018
Ackermann, Nature Reviews Microbiology, 13:497, 2015
Methods that will be used:
Quantitative Fluorescence Microscopy, Molecular Microbiology, Electron Microscopy, Microfluidics, Quantitative Image Analysis, Modeling (if desired)
Cooperation partners:
The lab collaborates with internal partners at the University of Heidelberg and the MPI for Terrestrial Microbiology as well as external partners around the world.
Personal qualifications:
(Micro)Biology, Systemsbiology, Biotechnology, Biophysics or related.
Keywords:
Microbiology, Microscopy, Bacillus subtilis, Spores, Single Cell Biology