Ruprecht-Karls-Universität Heidelberg
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Roth0118 - Scientist (f/m) / PhD position
Project no:
Roth0118

Project leader:

Project supervisor:
Roth, Susanne
Application deadline:
31. Aug 2018
Start of PhD project:
1. Sep 2018

Project description:

Title:
Tumor immunology in pancreatic cancer
Summary:
Our newly established, international and enthusiastic research group is a member of the excellence initiative of the German Cancer Aid (Max-Eder-Program) that focuses on translational pancreatic/gastrointestinal cancer research and is integrated in the European Pancreas Center (https://www.europaeisches-pankreaszentrum.de/extrainfo/international-office/) within an inspiring dynamic research environment in close collaboration with the group of Mathias Heikenwälder at the DKFZ (https://www.dkfz.de/en/chronische-entzuendung-und-krebs/index.php) and Wolfgang Huber at the EMBL (https://www.embl.de/research/units/genome biology/huber/). Our group studies how inflammatory responses influence gastrointestinal carcinogesis, especially in the pancreas. Specifically, we are interested in the detailed characterization of immune cell types and their interactions within the tumor microenvironment, understanding the molecular mechanisms that affect tumor cell growth, invasiveness and lead to therapy resistance in a translational research framework. To resolve heterogeneity in cell populations we apply single-cell technologies, combined with imaging and bioinformatic approaches. Our research findings are largely obtained from the direct study of patient-derived samples. An improved understanding of the (innate) immune signaling pathways that contribute to tumorigenesis could enable the development of novel immunotherapeutic strategies against these devastating diseases. In addition, we develop therapy response prediction methods for individualized treatment strategies that could be immediately administered clinically.

The candidate will join a multidisciplinary team within a stimulating atmosphere with excellent scientific working conditions, access to state-of-the-art instrumentation at the Heidelberg University biomedical campus, networks with experienced scientists and further training opportunities. Starting from August 1st 2018 we offer a PhD position for (initially) one year with the possibility of extension for 2-3 more years. Salary is paid according to the German public service scale based on candidates' background and experience (TV-L).
References:
Methods that will be used:
Cooperation partners:
Personal qualifications:
- MSc (or equivalent) in bioinformatics, biology, biotechnology, biochemistry, medicine, or a related field with preferentially a solid background in immunology, systems or cancer biology.
- Experiences in common molecular biology techniques, immune cell characterization (e.g. using flow cytometry, CyTOF), advanced cell culture techniques including derivation of primary cell cultures from human tissue specimens, histological and imaging methods, working with mouse models of human diseases, analysis of large/high-dimensional data sets generated with high-throughput methods (e.g. scRNAseq data), applications of mathematical models and machine learning are favourable.
- Ability to work independently and collaboratively with colleagues from different disciplines
- Creative and innovative thinking paired with strong analytical skills
- Proactive attitude and enthusiasm for research
- Fluent written and spoken English
Keywords:
Tumor immunology, pancreatic cancer, bioinformatics