Ruprecht-Karls-Universität Heidelberg
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Hell018 - Scientist (f/m) / PhD position
Project no:
Hell018

Project leader:

Project supervisor:
Hell, Rüdiger
Application deadline:
31. Oct 2018
Start of PhD project:
1. Dec 2018

Project description:

Title:
Regulation of nutrient starvations responses by TOR in plants
Summary:
The proposed project is designed to addresses a fundamental and pivotal question of plant research: How is are protein translation, meristem activity and autophagy regulated under nutrient deficiency to achieve acclimative optimal growth responses?
The sensor kinase ’Target of Rapamycin’ (TOR) is one of the central growth regulators in higher eukaryotes. We selected sulfur metabolism as a proxy for nutrient-deficiency based signaling, since reduced sulfur is incorporated into the amino acid cysteine. Cysteine synthesis is the convergence point of sulfur, nitrogen and carbon incorporation and thus at the heart of primary anabolism of photo-autotrophic plants. The expected results will be used as a blueprint to understand the basic principles of TOR regulation in response to other nutrients like carbon, nitrogen and phosphorous. This will be highly relevant to engineer nutrient use efficiency in crop plants.
References:
Pfeiffer et al. (2016) eLife
Dong et al. (2017) Nat. Comm.
Methods that will be used:
Gene expression profiling, metabolomics, confocal microscopy, biochemistry
Cooperation partners:
Heidelberg, Paris (France), China (Hefei)
Personal qualifications:
We look for highly motivated young scientists with interest in molecular genetics and processes of cellular regulation. Practical experience in molecular biology, biochemistry or cell biology will be of benefit. The applicants should hold a M.Sc. or PhD in Biology, Biochemistry or other relevant subjects.
Keywords:
Growth regulation, sensor kinases, translation regulation, nutrition