Ruprecht-Karls-Universität Heidelberg
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SFB 1158_Groh0119 - Scientist (f/m) / PhD position
Project no:
SFB 1158_Groh0119

Project leader:

Project supervisor:
Groh, Alexander
Application deadline:
30. Nov 2019
Start of PhD project:
1. Jan 2020

Project description:

Title:
Cellular mechanisms of nociception and nociceptive modulation in lateral and medial thalamocortical circuits of mice
Summary:
We are currently seeking a highly motivated and adventurous Ph.D. student to study neuronal and circuit mechanisms of nociception (pain) in the thalamocortical system. The project combines optogenetics and large-scale electrophysiology in mice and is supported by the second funding period of the Heidelberg Pain Consortium SFB1158 (www.sfb1158.de).
References:
• Multiplexed spike coding and adaptation in the thalamus. R.A. Mease, T. Kuner, A.L. Fairhall, and A. Groh. Cell Reports. (2017).

• Corticothalamic spike transfer via the L5B-POm pathway in vivo. R.A. Mease, A. Sumser, B. Sakmann and A. Groh. Cerebral Cortex. (2016).

• Cortical control of adaptation and sensory relay mode in the thalamus. R.A. Mease, P. Krieger and A. Groh. Proceedings of the National Academy of Sciences USA. (2014).
Methods that will be used:
electrophysiology, optogenetics, in vivo, behavior, mathematical/computational modeling, patch-clamp, high density silicon probe recordings, cFOS circuit mapping
Cooperation partners:
Heidelberg Pain Consortium SFB1158
Personal qualifications:
Applicants should hold a diploma/Masters in a biomedical discipline (e.g. neuroscience, biology, medicine) or in a quantitative discipline (e.g. physics, informatics, mathematics, biomedical-engineering) or similar. Previous experience in data analysis or programming using MATLAB/Python/R etc. is strongly preferred. Experience in methods to obtain and interpret neurophysiological data, and /or behavioral assays is highly desirable. Applicants with strong analytical skills and a flair for handling large datasets are particularly encouraged to apply. The working language in the lab is English.
Keywords:
cortico-subcortical interactions, nociceptive circuits, thalamus, sensori-emotional transformation