Ruprecht-Karls-Universität Heidelberg
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Bruegger0119 - Scientist (f/m) / PhD position
Project no:

Project leader:

Project supervisor:
Brügger, Britta
Application deadline:
30. Sep 2019
Start of PhD project:
1. Nov 2019

Project description:

Specific interactions of lipids with protein transmembrane segments
Membrane lipids not only serve as structural components of membranes but are also important modulators of protein function. Based on our observation of a specific protein-sphingolipid interaction that modulates the protein’s activity, we have identified by proteome-wide mapping approaches additional protein candidates specifically interacting with either sphingolipids or cholesterol. Using an interdisciplinary approach, the PhD student will be characterising structural and functional aspects of lipid interactions of a respective candidate protein that already went through a validation analysis. The project is supported by mass spectrometric analyses of lipids.
Methods that will be used:
Chemical biology approaches, biochemistry, cell biology, lipidomics
Cooperation partners:
Collaborations within TRR83; external collaboration partners: Prof. Jens Brüning (Cologne), Prof. Christian Freund (Berlin), Prof. James Drake (Albany, USA)
Personal qualifications:
We are looking for enthusiastic students with a master degree in the Life Sciences with practical experience in chemical biology, biochemistry and/or cell biology.
Protein-lipid interactions, membrane microdomains, lipidomics, trafficking, myelination processes