Ruprecht-Karls-Universität Heidelberg
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Publications by HBIGS PhD students:

Publications in 2018

Glomstad B, Zindler F, Jenssen BM, Booth AM (2018) Dispersibility and dispersion stability of carbon nanotubes in synthetic aquatic growth media and natural freshwater. Chemosphere, 201, 269-277

Sultan CS, Saackel A, Stank A, Fleming T, Fedorova M, Hoffmann R, Wade RC, Hecker M, Wagner AH (2018) Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells. Redox Biol, 16, 113-122

Kats I, Khmelinskii A, Kschonsak M, Huber F, Knieß R, Bartosik A, Knop M (2018) Mapping degradation signals and pathways in a eukaryotic N-terminome. Mol Cell, 70, 3, 488-501

Tsvilovskyy V, Solís-López A, Schumacher D, Medert R, Roers A, Kriebs U, Freichel M (2018) Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis. Cell Calcium 71:24-33

Rüthnick D, Schiebel E (2018) Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body. Cells, 7, 5

Speiser A, Silbermann M, Dong Y, Haberland S, Uslu VV, Wang S, Bangash SAK, Reichelt M, Meyer AJ, Wirtz M, Hell R (2018) Sulfur partitioning between glutathione and protein synthesis determines plant growth. Plant Physiol, doi: 10.1104/pp.18.00421

Hoffmann A, Dege T, Kunze R, Ernst AS, Lorenz H, Böhler LI, Korff T, Marti HH, Heiland S, Bendszus M, Helluy X, Pham M (2018) Early Blood-Brain Barrier Disruption in Ischemic Stroke Initiates Multifocally Around Capillaries/Venules. Stroke, doi: 10.1161/STROKEAHA.118.020927

Öztürk MA, Cojocaru V, Wade RC (2018) Dependence of Chromatosome Structure on Linker Histone Sequence and Posttranslational Modification. Biophys J, doi: 10.1016/j.bpj.2018.04.034

Katsinelos T, Zeitler M, Dimou E, Karakatsani A, Müller HM, Nachman E, Steringer JP, Ruiz de Almodovar C, Nickel W, Jahn TR (2018) Unconventional Secretion Mediates the Trans-cellular Spreading of Tau. Cell Rep, 23, 7, 2039-2055

Warsow G*, Huebschmann D*, ...Schlesner M, Sültmann H, Hohenfellner M, Duensing S (*equal contribution) (2018) Genomic features of renal cell carcinoma with venous tumor thrombus. Sci Rep, 8, 1, 7477

de Sena Cortabitarte A, Berkel S, Cristian FB, Fischer C, Rappold GA (2018) A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders J Neurodev Disord, 10, 1, 15

Boehler S, Lörracher AK, Schubert J, Braunbeck T (2018) Comparative live-imaging of in vivo EROD (ethoxyresorufin-O-deethylase) induction in zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) embryos after exposure to PAHs and river sediment extracts. Sci Total Environ, 621, 827-838

Schopp IM, Béthune J (2018) Split-BioID - Proteomic Analysis of Context-specific Protein Complexes in Their Native Cellular Environment. J Vis Exp, doi: 10.3791/57479

Paredes I, Himmels P, Ruiz de Almodóvar C (2018) Neurovascular Communication during CNS Development. Dev Cell, 45, 1, 10-32

Litke C, Bading H, Mauceri D (2018) Histone deacetylase 4 shapes neuronal morphology via a mechanism involving regulation of expression of Vascular Endothelial Growth Factor D. J Biol Chem, doi: 10.1074/jbc.RA117.001613

Montalbano A, Juergensen L, Fukami M, Thiel CT, Hauer NH, Roeth R, Weiss B, Naiki Y, Ogata T, Hassel D, Rappold GA (2018) Functional missense and splicing variants in the retinoic acid catabolizing enzyme CYP26C1 in idiopathic short stature. Eur J Hum Genet, doi: 10.1038/s41431-018-0148-9

Kuk H, Arnold C, Wagner AH, Hecker M, Sticht C, Korff T (2018) Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice. Front Physiol, 9, 320

Dimou E, Nickel W (2018) Unconventional mechanisms of eukaryotic protein secretion. Curr Biol, 28, 8, R406-R410

Andrea Rocker, Madeleine Peschke, Tiia Kittilä, Roman Sakson, Clara Brieke and Anton Meinhart. (2018) The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis. Nature Communications, 9(1):1686. doi: 10.1038/s41467-018-03652-8

Muthinja JM, Ripp J, Krüger T, Imle A, Haraszti T, Fackler OT, Spatz JP, Engstler M, Frischknecht F (2018) Tailored environments to study motile cells and pathogens. Cell Microbiol, 20, 3

Chase AJ, Wombacher R, Fackler OT (2018) Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef. J Biol Chem, doi: 10.1074/jbc.RA118.002794

Sachdeva R, Schlotterer A, Schumacher D, Matka C, Mathar I, Dietrich N, Medert R, Kriebs U, Lin J, Nawroth P, Birnbaumer L, Fleming T, Hammes HP, Freichel M. (2018) TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation. Mol Metab.9:156-167.

Abu El Maaty MA, Almouhanna F, Wölfl S (2018) Expression of TXNIP in Cancer Cells and Regulation by 1,25(OH)2D3: Is It Really the Vitamin D3 Upregulated Protein? Int J Mol Sci, 19, 3, 796

Poppelreuther M*, Sander S*, Minden F, Dietz MS, Exner T, Du C, Zhang I, Ehehalt F, Knüppel L, Domschke S, Badenhop A, Staudacher S, Ehehalt R, Stremmel W, Thiele C, Heilemann M, Füllekrug J (*equal contribution) (2018) The metabolic capacity of lipid droplet localized acyl-CoA synthetase 3 is not sufficient to support local triglyceride synthesis independent of the endoplasmic reticulum in A431 cells. Biochim Biophys Acta, doi: 10.1016/j.bbalip.2018.03.003.

Duffey M, Sanchez CP, Lanzer M (2018) Profiling of the anti-malarial drug candidate SC83288 against artemisinins in Plasmodium falciparum. Malar J, 17, 1, 121

Bucher D, Frey F, Sochacki KA, Kummer S, Bergeest JP, Godinez WJ, Kräusslich HG, Rohr K, Taraska JW, Schwarz US, Boulant S (2018) Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis. Nat Commun, 9, 1, 1109

Platten M, Bunse L, Riehl D, Bunse T, Ochs K, Wick W (2018) Vaccine Strategies in Gliomas. Curr Treat Options Neurol, 20, 5, 11

Wirthschaft P, Bode J, Simon AEM, Hoffmann E, van Laack R, Krüwel T, Dietrich F, Bucher D, Hahn A, Sahm F, Breckwoldt MO, Kurz FT, Hielscher T, Fischer B, Dross N, Ruiz de Almodovar C, von Deimling A, Herold-Mende C, Plass C, Boulant S, Wiestler B, R (2018) A PRDX1-p38α heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas. Int J Cancer, doi: 10.1002/ijc.31404

Alvisi G, Paolini L, Contarini A, Zambarda C, Di Antonio V, Colosini A, Mercandelli N, Timmoneri M, Palù G, Caimi L, Ricotta D, Radeghieri A (2018) Intersectin goes nuclear: secret life of an endocytic protein. Biochem J, doi: 10.1042/BCJ20170897

Dimitrov B, Himmelreich N, Hipgrave Ederveen AL, Lüchtenborg C, Okun JG, Breuer M, Hutter AM, Carl M, Guglielmi L, Hellwig A, Thiemann KC, Jost M, Peters V, Staufner C, Hoffmann GF, Hackenberg A, Paramasivam N, Wiemann S, Eils R, Schlesner M...Thiel (2018) Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. Mol Genet Metab, 123, 3, 364-374

Grünvogel O, Colasanti O, Lee JY, Klöss V, Belouzard S, Reustle A, Esser-Nobis K, Hesebeck-Brinckmann J, Mutz P, Hoffmann K, Mehrabi A, Koschny R, Vondran FWR, Gotthardt D, S...Bartenschlager R, Dubuisson J, Dalpke AH, Lohmann V (2018) Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll Like Receptor 3 in Hepatocytes. Gastroenterology, doi: 10.1053/j.gastro.2018.03.020

Zhang Z, Filzmayer C, Ni Y, Sültmann H, Mutz P, Hiet MS, Vondran FWR, Bartenschlager R, Urban S (2018) Hepatitis D Virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes. J Hepatol, doi: 10.1016/j.jhep.2018.02.021

Heigwer F, Port F, Boutros M (2018) RNA Interference (RNAi) Screening in Drosophila. Genetics, 208, 3, 853-874

Sachdeva R, Schlotterer A, Schumacher D, Matka C, Mathar I, Dietrich N, Medert R, Kriebs U, Lin J, Nawroth P, Birnbaumer L, Fleming T, Hammes HP, Freichel M (2018) TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation. Mol Metabolism, http://dx.doi.org/10.1016/j.molmet.2018.01.003

Naharros IO, Cristian FB, Zang J, Gesemann M, Ingham PW, Neuhauss SCF, Bachmann-Gagescu R (2018) The ciliopathy protein TALPID3/KIAA0586 acts upstream of Rab8 activation in zebrafish photoreceptor outer segment formation and maintenance. Sci Rep, 8, 1, 2211

Zhang W, Neuner A, Rüthnick D, Sachsenheimer T, Lüchtenborg C, Brügger B, Schiebel E (2018) Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis. J Cell Biol, doi: 10.1083/jcb.201706024

Takemoto K, Ebine K, Askani JA, Krüger F, Gonzalez ZA,Ito E, Goh T, Schumacher K, Nakano A, Ueda T (2018) Distinct sets of tethering complexes, SNARE complexes, and Rab GTPases mediate membrane fusion at the vacuole in Arabidopsis Proc Natl Acad Sci U S A, https://doi.org/10.1073/pnas.1717839115

Voloshanenko O, Schwartz U, Kranz D, Rauscher B, Linnebacher M, Augustin I, Boutros M (2018) β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells. Sci Rep, 8, 1, 3178

Vlijm R, Li X, Panic M, Rüthnick D, Hata S, Herrmannsdörfer F, Kuner T, Heilemann M, Engelhardt J, Hell SW, Schiebel E (2018) STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles. Proc Natl Acad Sci U S A, https://doi.org/10.1073/pnas.1716840115

Mulindwa J, Leiss K, Ibberson D, Kamanyi Marucha K, Helbig C, Melo do Nascimento L, Silvester E, Matthews K, Matovu E, Enyaru J, Clayton C (2018) Transcriptomes of Trypanosoma brucei rhodesiense from sleeping sickness patients, rodents and culture: Effects of strain, growth conditions and RNA preparation methods. PLoS Negl Trop Dis, 12, 2, e0006280

Garcia Del Arco A, Edgar BA, Erhardt S (2018) In Vivo Analysis of Centromeric Proteins Reveals a Stem Cell-Specific Asymmetry and an Essential Role in Differentiated, Non-proliferating Cells. Cell Rep, 22, 8, 1982-1993

Li C, Cesbron F, Oehler M, Brunner M, Höfer T (2018) Frequency Modulation of Transcriptional Bursting Enables Sensitive and Rapid Gene Regulation. Cell Syst, doi: 10.1016/j.cels.2018.01.012

Gröbner SN...Huebschmann D...Pfister SM (2018) The landscape of genomic alterations across childhood cancers. Nature, doi: 10.1038/nature25480

Brackmann K, Qi J, Gebert M, Jouannet V, Schlamp T, Grünwald K, Wallner ES, Novikova DD, Levitsky VG, Agustí J, Sanchez P, Lohmann JU, Greb T (2018) Spatial specificity of auxin responses coordinates wood formation. Nat Commun, 9, 1, 875

Gülmez Karaca K, Brito DVC, Zeuch B, Oliveira AMM (2018) Adult hippocampal MeCP2 preserves the genomic responsiveness to learning required for long-term memory formation. Neurobiol Learn Mem, 149, 84-97

Wiedenmann T, Dietrich N, Fleming T, Altamura S, Deelman LE, Henning RH, Muckenthaler MU, Nawroth PP, Hammes HP, Wagner AH, Hecker M (2018) Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice. J Diabetes Complications, 32, 2, 130

Rauscher B, Heigwer F, Henkel L, Hielscher T, Voloshanenko O, Boutros M (2018) Toward an integrated map of genetic interactions in cancer cells. Mol Syst Biol, 14, 2, e7656

Mutlu A, Trauth S, Ziesack M, Nagler K, Bergeest JP, Rohr K, Becker N, Höfer T, Bischofs IB (2018) Phenotypic memory in Bacillus subtilislinksdormancy entry and exit by a spore quantity-quality tradeoff. Nat Commun, 9, 1, 69

Coquelle N, Sliwa M, Woodhouse J, Schirò G, Adam V, Aquila A, Barends TRM, Boutet S, Byrdin M, Carbajo S, De la Mora E, Doak RB, Feliks M, Fieschi F, Foucar L, Guillon V, Hilpert M, Hunter MS, Jakobs S, Koglin JE, Kovácsová G,...Schlichting I, Weik M (2018) Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography. Nat Chem, 10, 1, 31-37

Arnold C, Demirel E, Feldner A, Genové G, Zhang H, Sticht C, Wieland T, Hecker M, Heximer S, Korff T (2018) Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J, doi: 10.1096/fj.201700384RR

Theobald J, Ghanem A, Wallisch P, Banaeiyan AA, Andrade-Navarro MA, Taškova K, Haltmeier M, Kurtz A, Becker H, Reuter S, Mrowka R, Cheng X, Wölfl S (2018) Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites. ACS Biomater Sci Eng, 4, 1, 78–89

Grousl T, Ungelenk S, Miller S, Ho CT, Khokhrina M, Mayer MP, Bukau B, Mogk A (2018) A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins. J Cell Biol, doi: 10.1083/jcb.201708116

Schmelas C, Grimm D (2018) Split Cas9, not hairs - advancing the therapeutic index of CRISPR technology. Biotechnol J, doi: 10.1002/biot.201700432

Ebersoll S, Musunda B, Schmenger T, Dirdjaja N, Bonilla M, Manta B, Ulrich K, Comini MA, Krauth-Siegel RL (2018) A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes. Redox Biol, 15, 532-547