Ruprecht-Karls-Universität Heidelberg
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Publications by HBIGS PhD students:

Publications in 2019

Stanifer ML, Mukenhirn M, Muenchau S, Pervolaraki K, Kanaya T, Albrecht D, Odendall C, Hielscher T, Haucke V, Kagan JC, Bartfeld S, Ohno H, Boulant S (2019) Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells. Nat Microbiol, doi: 10.1038/s41564-019-0594-3

Demirdizen E, Spiller-Becker M, Förtsch A, Wilhelm A, Corless S, Bade D, Bergner A, Hessling B, Erhardt S (2019) Localization of Drosophila CENP-A to non-centromeric sites depends on the NuRD complex. Nucleic Acids Res, doi: 10.1093/nar/gkz962.

Marques, Oriana; Neves, Joana; Horvat, Natalie K.; Colucci, Silvia; Guida, Claudia; Muckenthaler, Martina (2019) Iron-Related Parameters are Altered Between C57BL/6N and C57BL/6J Mus Musculus Wild-Type Substrains -

Christina Ising, Carmen Venegas, Shuangshuang Zhang, Hannah Scheiblich, Susanne V. Schmidt, Ana Vieira-Saecker, Stephanie Schwartz, Shadi Albasset, Róisín M. McManus, Dario Tejera, Angelika Griep, Francesco Santarelli, Frederic Brosseron, Sabine Opit (2019) NLRP3 inflammasome activation drives tau pathology doi:10.1038/s41586-019-1769-z

du Plessis B, Regnier T, Combrinck S, Heinrich P, Braunbeck T (2019) Effect of pH on the toxicity of fumonisins towards the RTL-W1 cell line and zebrafish (Danio rerio) embryos. Toxicol Lett, doi: 10.1016/j.toxlet.2019.06.009

Imle R, Wang BT, Stützenberger N, Birkenhagen J, Tandon A, Carl M, Himmelreich N, Thiel C, Gröne HJ, Poschet G, Völkers M, Gülow K, Schröder A, Carillo S, Mittermayr S, Bones J, Kamiński MM, Kölker S, Sauer SW (2019) ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing. Sci Rep, doi: 10.1038/s41598-019-50566-6

Aziz W, Kraev I, Mizuno K, Kirby A, Fang T, Rupawala H, Kasbi K, Rothe S, Jozsa F, Rosenblum K, Stewart MG, Giese KP (2019) Multi-input Synapses, but Not LTP-Strengthened Synapses, Correlate with Hippocampal Memory Storage in Aged Mice. Current Biol, 29, 1–11

Chiang MH, Greb T (2019) How to organize bidirectional tissue production? Curr Opin Plant Biol, doi: 10.1016/j.pbi.2019.03.003

Holzwart E, Wanke F, Glöckner N, Höfte H, Harter K, Wolf S (2019) A mutant allele uncouples the brassinosteroid-dependent and independent functions of BRASSINOSTEROID INSENSITIVE 1. Plant Physiol, doi: 10.1104/pp.19.00448

Palanisamy N, Degen A, Morath A, Ballestin Ballestin J, Juraske C, Öztürk MA, Sprenger GA, Youn JW, Schamel WW, Di Ventura B (2019) Split intein-mediated selection of cells containing two plasmids using a single antibiotic. Nat Commun, doi: 10.1038/s41467-019-12911-1

Herold R, Schroten H, Schwerk C (2019) Virulence Factors of Meningitis-Causing Bacteria: Enabling Brain Entry across the Blood-Brain Barrier. Int J Mol Sci, doi: 10.3390/ijms20215393.

Hata S, Pastor Peidro A, Panic M, Liu P, Atorino E, Funaya C, Jäkle U, Pereira G, Schiebel E (2019) The balance between KIFC3 and EG5 tetrameric kinesins controls the onset of mitotic spindle assembly. Nat Cell Biol, doi: 10.1038/s41556-019-0382-6

Gulmez Karaca K, Brito DVC, Oliveira AMM (2019) MeCP2: A Critical Regulator of Chromatin in Neurodevelopment and Adult Brain Function. Int J Mol Sci, doi:10.3390/ijms20184577

Höglinger D, Burgoyne T, Sanchez-Heras E, Hartwig P, Colaco A, Newton J, Futter CE, Spiegel S, Platt FM, Eden ER (2019) NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress. Nature Commun, doi: 10.1038/s41467-019-12152-2

Venkataramani V, Tanev DI, Strahle C, ..., Agarwal A, Bergles DE, Chalmers A, Miletic H, Turcan S, Mawrin C, Hänggi D, Liu HK, Wick W, Winkler F, Kuner T (2019) Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature, doi: 10.1038/s41586-019-1564-x

Nunes TDG*, Zhang D*, Raissig MT (*equal contribution) (2019) Form, development and function of grass stomata. Plant J, doi: 10.1111/tpj.14552

Armbruster L, Uslu VV, Wirtz M, Hell R (2019) The Recovery from Sulfur Starvation Is Independent from the mRNA Degradation Initiation Enzyme PARN in Arabidopsis. Plants (Basel), doi: 10.3390/plants8100380.

Lee JS, Tabata K, Twu WI, Rahman MS, Kim HS, Yu JB, Jee MH, Bartenschlager R, Jang SK (2019) RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection. PLoS Pathogens / 15(9):e1008021

Würtz M, Aumiller D, Gundelwein L, Jung P, Schütz C, Lehmann K, Tóth K, Rohr K (2019) DNA accessibility of chromatosomes quantified by automated image analysis of AFM data. Sci Rep, doi: 10.1038/s41598-019-49163-4

Geller SH, Antwi EB, Di Ventura B, McClean MN (2019) Optogenetic Repressors of Gene Expression in Yeasts Using Light-Controlled Nuclear Localization. Cell Mol Bioeng, doi: 10.1007/s12195-019-00598-9

Herrmann S, Zhan T, Betge J, Rauscher B, Belle S, Gutting T, Schulte N, Jesenofsky R, Haertel N, Gaiser T, Hofheinz R, Ebert M, Boutros M (2019) Detection of mutational patterns in cell free DNA (cfDNA) of colorectal cancer by custom amplicon sequencing. Mol Oncol, 13, 8, 1669-1683

Kühnle N, Dederer V, Lemberg MK (2019) Intramembrane proteolysis at a glance: from signalling to protein degradation. J Cell Sci, doi: 10.1242/jcs.217745

Doroudgar S, Hofmann C, Boileau E, Malone B, Riechert E, Gorska AA, Jakobi T, Sandmann C, Jürgensen L, Kmietczyk V, Malovrh E, Burghaus J, Rettel M, Stein F, Younesi F, Friedrich UA, Mauz V, Backs J, Kramer G, Katus HA, Dieterich C, Völkers M (2019) Monitoring Cell-Type-Specific Gene Expression Using Ribosome Profiling In Vivo During Cardiac Hemodynamic Stress. Circ Res, doi: 10.1161/CIRCRESAHA.119.314817

Bergheim BG, Özbek S (2019) Extracellular matrix and morphogenesis in cnidarians: a tightly knit relationship. Essays Biochem, doi: 10.1042/EBC20190021

Vilches Barro A, Stöckle D, Thellmann M, Ruiz-Duarte P, Bald L, Louveaux M, von Born P, Denninger P, Goh T, Fukaki H, Vermeer JEM, Maizel A (2019) Cytoskeleton Dynamics Are Necessary for Early Events of Lateral Root Initiation in Arabidopsis. Curr Biol, doi: 10.1016/j.cub.2019.06.039

Wild K, Becker MMM, Kempf G, Sinning I (2019) Structure, dynamics and interactions of large SRP variants. Biol Chem, doi: 10.1515/hsz-2019-0282

Fröhlich B, Jäger J, Lansche C, Sanchez CP, Cyrklaff M, Buchholz B, Soubeiga ST, Simpore J, Ito H, Schwarz US, Lanzer M, Tanaka M (2019) Hemoglobin S and C affect biomechanical membrane properties of P. falciparum-infected erythrocytes. Commun Biol, doi: 10.1038/s42003-019-0556-6

Midori Kjellin, Hege Kileng, Dario Akaberi, Navaneethan Palanisamy, Ann-Sofi Duberg, Astrid Danielsson, Magnhild Gangsøy Kristiansen, Johan Nöjd, Soo Aleman, Tore Gutteberg, Rasmus Goll, Anders Lannergård & Johan Lennerstrand (2019) Effect of the baseline Y93H resistance-associated substitution in HCV genotype 3 for direct-acting antiviral treatment: real-life experience from a multicenter study in Sweden and Norway. Scand J Gastroenterol. 54(8):1042-1050.

Bageritz J, Willnow P, Valentini E, Leible S, Boutros M, Teleman AA (2019) Gene expression atlas of a developing tissue by single cell expression correlation analysis. Nature Methods, doi: https://doi.org/10.1101/477125

Buchmuller BC*, Herbst K*, Meurer M, Kirrmaier D, Sass E, Levy ED, Knop M (*equal contribution) (2019) Pooled clone collections by multiplexed CRISPR-Cas12a-assisted gene tagging in yeast. Nat Commun, doi: 10.1038/s41467-019-10816-7

Sanchez CP, Moliner Cubel S, Nyboer B, Jankowska-Döllken M, Schaeffer-Reiss C, Ayoub D, Planelles G, Lanzer M (2019) Phosphomimetic substitution at Ser-33 of the chloroquine resistance transporter PfCRT reconstitutes drug responses in Plasmodium falciparum. J Biol Chem, doi: 10.1074/jbc.RA119.009464

Sandhof CA, Hoppe SO, Druffel-Augustin S, Gallrein C, Kirstein J, Voisine C, Nussbaum-Krammer C (2019) Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. Autophagy, doi 10.1080/15548627.2019.1643657

Benedetto A, Bambade T, Au C, Tullet JMA, Monkhouse J, Dang H, Cetnar K, Cabreiro F, Chan B, Gems D (2019) New label-free automated survival assays reveal unexpected stress resistance patterns during C. elegans aging.
Aging Cell, doi: 10.1111/acel.12998

Fu RM*, Decker CC*, Dao Thi VL (*equal contribution) (2019) Cell Culture Models for Hepatitis E Virus. Viruses, doi: 10.3390/v11070608

Hoffmann S, Paone C, Sumer SA, Diebold S, Weiss B, Roeth R, Clauss S, Klier I, Kääb S, Schulz A, Wild PS, Ghrib A, Zeller T, Schnabel RB, Just S, Rappold GA (2019) Functional Characterization of Rare Variants in the SHOX2 Gene Identified in Sinus Node Dysfunction and Atrial Fibrillation. Front Genet, doi: 10.3389/fgene.2019.00648

Schmitteckert S, Mederer T, Röth R, Günther P, Holland-Cunz S, Metzger M, Samstag Y, Schröder-Braunstein J, Wabnitz G, Kurzhals S, Scheuerer J, Beretta CA, Lasitschka F, Rappold GA, Romero P, Niesler B (2019) Postnatal human enteric neurospheres show a remarkable molecular complexity. Neurogastroenterol Motil, doi: 10.1111/nmo.13674

Nass Kovacs G, Colletier JP, Grünbein ML, Yang Y, Stensitzki T, Batyuk A, Carbajo S, Doak RB, Ehrenberg D, Foucar L, Gasper R, Gorel A, Hilpert M, Kloos M, Koglin JE, Reinstein J, Roome CM, Schlesinger R, Seaberg M, Shoeman RL, Stricker M, Boutet S, (2019) Three-dimensional view of ultrafast dynamics in photoexcited bacteriorhodopsin. Nat Commun, doi: 10.1038/s41467-019-10758-0

Longerich T, Endris V, Neumann O, Rempel E, Kirchner M, Abadi Z, Uhrig S, Kriegsmann M, Weiss KH, Breuhahn K, Mehrabi A, Weber TF, Wilkens L, Straub BK, Rosenwald A, Schulze F, Brors B, Froehling S, Pellegrino R, Budczies J, Schirmacher P, Stenzinger (2019) RSPO2 gene rearrangement: a powerful driver of β-catenin activation in liver tumours. Gut. / 68(7):1287-1296.

Peleh T*, Eltokhi A*, Pitzer C. (2019) Longitudinal analysis of ultrasonic vocalizations in mice from infancy to adolescence: Insights into the vocal repertoire of three wild-type strains in two different social contexts. Plos One

Shirin Doroudgar, Christoph Hofmann, Etienne Boileau, Brandon Malone, Eva Riechert, Agnieszka A. Gorska, Tobias Jakobi, Clara Sandmann, Lonny Jürgensen, Vivien Kmietczyk, Ellen Malovrh, Jana Burghaus, Mandy Rettel, Frank Stein, Fereshteh Younesi, Ulr (2019) Monitoring Cell-Type–Specific Gene Expression Using Ribosome Profiling In Vivo During Cardiac Hemodynamic Stress Circulation Research.125:431–448

Valls AF, Knipper K, Giannakouri E, Sarachaga V, Hinterkopf S, Wuehrl M, Shen Y, Radhakrishnan P, Klose J, Ulrich A, Schneider M, Augustin HG, Ruiz de Almodovar C, Schmidt T (2019) VEGFR1+ metastasis-associated macrophages contribute to metastatic angiogenesis and influence colorectal cancer patient outcome. Clin Cancer Res, doi: 10.1158/1078-0432.CCR-18-2123

Dederer V, Khmelinskii A, Huhn AG, Okreglak V, Knop M, Lemberg MK (2019) Cooperation of mitochondrial and ER factors in quality control of tail-anchored proteins. Elife, doi: 10.7554/eLife.45506

Zindler F, Beedgen F, Braunbeck T (2019) Time-course of coiling activity in zebrafish (Danio rerio) embryos exposed to ethanol as an endpoint for developmental neurotoxicity (DNT) – Hidden potential and underestimated challenges. Chemosphere, doi.org/10.1016/j.chemosphere.2019.06.154

Wagner N, Norlin N, Gierten J, de Medeiros G, Balázs B, Wittbrodt J, Hufnagel L, Prevedel R (2019) Instantaneous isotropic volumetric imaging of fast biological processes. Nat Methods, doi: 10.1038/s41592-019-0393-z.

Sarropoulos I, Marin R, Cardoso-Moreira M, Kaessmann H (2019) Developmental dynamics of lncRNAs across mammalian organs and species. Nature, doi: 10.1038/s41586-019-1341-x

Schlüter A, Aksan B, Fioravanti R, Valente S, Mai A, Mauceri D. (2019) Histone Deacetylases Contribute to Excitotoxicity-Triggered Degeneration of Retinal Ganglion Cells In Vivo. Molecular Neurobiology, S.1-17

Schulze-Edinghausen L, Dürr C, Öztürk S, Zucknick M, Benner A, Kalter V, Ohl S, Close V, Wuchter P, Stilgenbauer S, Lichter P, Seiffert M (2019) Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia. Cancers (Basel), doi: 10.3390/cancers11060822

Öztürk S, Roessner PM, Schulze-Edinghausen L, Yazdanparast H, Kalter V, Lichter P, Hanna BS, Seiffert M (2019) Rejection of adoptively transferred Eµ-TCL1 chronic lymphocytic leukemia cells in C57BL/6 substrains or knockout mouse lines. Leukemia, doi: 10.1038/s41375-018-0332-5

Frank T, Nawroth P, Kuner R (2019) Structure–function relationships in peripheral nerve contributions to diabetic peripheral neuropathy. Pain, doi: 10.1097/j.pain.0000000000001530

Münchau S, Deutsch R, de Castro IJ, Hielscher T, Heber N, Niesler B, Lusic M, Stanifer ML, Boulant S (2019) Hypoxic environment promotes barrier formation in human intestinal epithelial cells through regulation of miRNA-320a expression. Mol Cell Biol, doi: 10.1128/MCB.00553-18

Denninger P, Reichelt A, Schmidt VAF, Mehlhorn DG, Asseck LY, Stanley CE, Keinath NF, Evers JF, Grefen C, Grossmann G (2019) Distinct RopGEFs Successively Drive Polarization and Outgrowth of Root Hairs. Curr Biol, doi: 10.1016/j.cub.2019.04.059

Lytvynenko I, Paternoga H, Thrun A, Balke A, Müller TA, Chiang CH, Nagler K, Tsaprailis G, Anders S, Bischofs I, Maupin-Furlow JA, Spahn CMT, Joazeiro CAP (2019) Alanine Tails Signal Proteolysis in Bacterial Ribosome-Associated Quality Control Cell, 178, 1–15, https://doi.org/10.1016/j.cell.2019.05.002

Devant JM, Hofhaus G, Bhella D, Hansman GS (2019) Heterologous expression of human norovirus GII.4 VP1 leads to assembly of T=4 virus-like particles. Antiviral Res, doi: 10.1016/j.antiviral.2019.05.010

Upmeier zu Belzen J... Schmelas C ...Eils R (2019) Leveraging implicit knowledge in neural networks for functional dissection and engineering of proteins. Nature Machine Intelligence, 1, 225–235

Ahmed M, Legrand C, Yagüe Relimpio A, Beretta CA, Muschko A, Wegehingel S, Müller HM, Sehr P, Will DW, Lewis JD, Nickel W (2019) A time-resolved live cell imaging assay to identify small molecule inhibitors of FGF2 signaling. FEBS Lett, doi: 10.1002/1873-3468

Tisler S, Zindler F, Freeling F, Nodler K, Toelgyesi L, Braunbeck T, Zwiener C (2019) Transformation Products of Fluoxetine Formed by Photodegradation in Water and Biodegradation in Zebrafish Embryos (Danio rerio). Environ Sci Technol, 53,13, 7400

Spreng B, Fleckenstein H, Kübler P, Di Biagio C, Benz M, Patra P, Schwarz US, Cyrklaff M, Frischknecht F (2019) Microtubule number and length determine cellular shape and function in Plasmodium. EMBO J, doi: 10.15252/embj.2018100984

Zhan T, Ambrosi G, Wandmacher M, Rauscher B, Betge J, Rindtorff N, Haeussler R, Hinsenkamp I, Bamberg L, Hessling B, Mueller-Decker K, Erdmann G, Burgermeister E, Ebert M, Boutros M (2019) MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer. Nat Commun, 10, 1, 2197

Hu T, Schreiter FC, Bagchi RA, Tatman PD, Hannink M, McKinsey (2019) TAHDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression. J Biol Chem, doi: 10.1074/jbc.RA118.007006

Wei T, Weiler SME, Tóth M, Sticht C, Lutz T, Thomann S, De La Torre C, Straub B, Merker S, Ruppert T, Marquardt J, Singer S, Gretz N, Schirmacher P, Breuhahn K (2019) YAP-dependent induction of UHMK1 supports nuclear enrichment of the oncogene MYBL2 and proliferation in liver cancer cells. Oncogene, doi: 10.1038/s41388-019-0801-y

Ramakrishna P, Ruiz-Duarte P, Rance GA, Schubert M, Vordermaier V, Vu LD, Murphy E, Vilches-Barro A, Swarup K, Moirangthem K, Jørgensen B, van de Cotte B, Goh T, Lin Z, Voβ U, Beeckman T, Bennett MJ, Gevaert K, Maizel A, De Smet I (2019) EXPANSIN A1-mediated radial swelling of pericycle cells positions anticlinal cell divisions during lateral root initiation. Proc Natl Acad Sci U S A, doi: 10.1073/pnas.1820882116

Kumar D*, Golchoubian B*, Belevich I, Jokitalo E, Schlaitz AL (*equal contribution) (2019) REEP3 and REEP4 determine the tubular morphology of the endoplasmic reticulum during mitosis. Mol Biol Cell, doi: 10.1091/mbc.E18-11-0698

López-Salmerón V, Schürholz AK, Li Z, Schlamp T, Wenzl C, Lohmann JU, Greb T, Wolf S (2019) Inducible, Cell Type-Specific Expression in Arabidopsis thaliana Through LhGR-Mediated Trans-Activation. J Vis Exp, doi: 10.3791/59394

Duman C, Yaqubi K, Hoffmann A, Acikgöz AA, Korshunov A, Bendszus M, Herold-Mende C, Liu HK, Alfonso J (2019) Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation. Cell Metab, doi: 10.1016/j.cmet.2019.04.004

Bettenworth V, Steinfeld B, Duin H, Petersen K, Streit WR, Bischofs I, Becker A (2019) Phenotypic Heterogeneity in Bacterial Quorum Sensing Systems. J Mol Biol, doi: 10.1016/j.jmb.2019.04.036

Mehnert AK*, Simon CS*, Guizetti J (*equal contribution) (2019) Immunofluorescence staining protocol for STED nanoscopy of Plasmodium-infected red blood cells. Mol Biochem Parasitol, doi: 10.1016/j.molbiopara.2019.02.007

Tabatabai J, Fakhiri J, Meyburg J, Linse KP, Xu M, Söderlund-Venermo M, Grimm D, Schnitzler P (2019) Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome. Pediatr Infect Dis J, doi: 10.1097/INF.0000000000002354

Hoffmann MD, Aschenbrenner S, Grosse S, Rapti K, Domenger C, Fakhiri J, Mastel M, Börner K, Eils R, Grimm D, Niopek D (2019) Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins. Nucleic Acids Res, doi: 10.1093/nar/gkz271

Kmietczyk V, Riechert E, Kalinski L, Boileau E, Malovrh E, Malone B, Gorska A, Hofmann C, Varma E, Jürgensen L, Kamuf-Schenk V, Altmüller J, Tappu R, Busch M, Most P, Katus HA, Dieterich C, Völkers M (2019) m6A-mRNA methylation regulates cardiac gene expression and cellular growth. Life Sci Alliance, doi: 10.26508/lsa.201800233

Stöth M, Valls AF, Chen M, Hidding S, Knipper K, Shen Y, Klose J, Ulrich A, Ruiz de Almodovar C, Schneider M, Schmidt T (2019) Splenectomy reduces lung metastases and tumoral and metastatic niche inflammation. Int J Cancer, doi: 10.1002/ijc.32378

Diederichs S, Tonnier V, Marz M, Dreher SI, Geisbusch A, Richter W (2019) Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy. Cell Mol Life Sci, doi:10.1007/s00018-019-03099-0

Selbach C, Rosenkranz M, Poulin R (2019) Cercarial Behavior Determines Risk of Predation. J Parasitol, 105, 2, 330-333

Akram M, Dietl A, Mersdorf U, Prinz S, Maalcke W, Keltjens J, Ferousi C, de Almeida NM, Reimann J, Kartal B, Jetten MSM, Parey K, Barends TRM (2019) A 192-heme electron transfer network in the hydrazine dehydrogenase complex. Sci Adv, doi: 10.1126/sciadv.aav4310

Yilmaz OK, Haeberle S, Zhang M, Fritzler MJ, Enk AH, Hadaschik EN (2019) Scurfy Mice Develop Features of Connective Tissue Disease Overlap Syndrome and Mixed Connective Tissue Disease in the Absence of Regulatory T Cells. Front Immunol, doi: 10.3389/fimmu.2019.00881

Bragado Alonso S, Reinert JK, Marichal N, Massalini S, Berninger B, Kuner T, Calegari F (2019) An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants. EMBO J, 38, 6, e98791, doi: 10.15252/embj.201798791

Sachdeva R, Fleming T, Schumacher D, Homberg S, Stilz K, Mohr F, Wagner AH, Tsvilovskyy V, Mathar I, Freichel M (2019) Methylglyoxal evokes acute Ca2+ transients in distinct cell types and increases agonist-evoked Ca2+ entry in endothelial cells via CRAC channels. Cell Calcium, 78, 66-75

Moraes CB, Witt G ... Pöhner I ... Wade RC ... Gul S (2019) Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform. SLAS Discovery, 24, 3, 346-361

Hammouda OT, Böttger F, Wittbrodt J, Thumberger T (2019) Swift Large-scale Examination of Directed Genome Editing. PLoS One, 14, 3, e0213317

López-Salmerón V, Cho H, Tonn N, Greb T (2019) The Phloem as a Mediator of Plant Growth Plasticity. Curr Biol, 29, 5, 173

Lischik CQ, Adelmann L, Wittbrodt J (2019) Enhanced in vivo-imaging in medaka by optimized anaesthesia, fluorescent protein selection and removal of pigmentation. PLoS One, 14, 3, e0212956

Yücel SS, Stelzer W, Lorenzoni A, Wozny M, Langosch D, Lemberg MK (2019) The Metastable XBP1u Transmembrane Domain Defines Determinants for Intramembrane Proteolysis by Signal Peptide Peptidase. Cell Rep, 26, 3087–3099

Schmidt RM, Schessner JP, Borner GH, Schuck S (2019) The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance. Elife, doi: 10.7554/eLife.43244

Hübner JM, Müller T, Papageorgiou DN, Mauermann M, Krijgsveld J, Russell RB, Ellison DW, Pfister SM, Pajtler KW, Kool M (2019) EZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma. Neuro Oncol, doi.org/10.1093/neuonc/noz058

Yang Y, Lenherr E, Gromes R, Wang S, Wirtz M, Hell R, Peskan-Berghöfer T, Scheffzek K, Rausch T (2019) Plant glutathione biosynthesis revisited: Redox-mediated activation of glutamylcysteine ligase does not require homo-dimerization. Biochem J, doi: 10.1042/BCJ20190072

Tsingos E, Höckendorf B, Sütterlin T, Kirchmaier S, Grabe N, Centanin L, Wittbrodt J (2019) Retinal stem cells modulate proliferative parameters to coordinate post-embryonic morphogenesis in the eye of fish. Elife, 8, e42646.

Fakhiri J, Nickl M, Grimm D (2019) Rapid and Simple Screening of CRISPR Guide RNAs (gRNAs) in Cultured Cells Using Adeno-Associated Viral (AAV) Vectors. Methods Mol Biol, 1961, 111-126

Heinrich P, Braunbeck T (2019) Bioavailability of microplastic-bound pollutants in vitro: The role of adsorbate lipophilicity and surfactants. Comp Biochem Physiol C Toxicol Pharmacol, doi: 10.1016/j.cbpc.2019.03.012

Kalamikis, G., D. Brune, S. Ravichandran, J. Bolz, W. Fan, F. Ziebell, T. Stiehl, F. Catala-Martinez, J. Kupke, S. Zhao, E. Llorens-Bobadilla, K. Bauer, S. Limpert, B. Berger, U. Christen, P. Schmezer, J. P. Mallm, B. Berninger, S. Anders, A. Del Sol (2019) Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain. Cell 176(6): 1407-1419 e1414.

Liu Y, Mi Y, Müller T, Kreibich S, Williams EG, Van Drogen A, Borel C, Frank M, Germain PL, Bludau I, Mehnert M, Seifert M, Emmenlauer M, Sorg I, Bezrukov F, Bena FS, Zhou H, Dehio C, Testa G, Saez-Rodriguez J, Antonarakis SE, Hardt WD, Aebersold R (2019) Multi-omic measurements of heterogeneity in HeLa cells across laboratories. Nat Biotechnol, doi: 10.1038/s41587-019-0037-y

Yan Y, Rato C, Rohland L, Preissler S, Ron D (2019) MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat Commun, 10, 1, 541

Niemeyer J*, Mentrup T*, Heidasch R*, Müller SA, Biswas U, Meyer R, Papadopoulou AA, Dederer V, ..., Lichtenthaler SF, Lemberg MK, Schröder B (*equal contibution) (2019) The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban. EMBO Rep, doi: 10.15252/embr.201846449

Guerra M, Frey D, Hagner M, Dittrich S, Paulsen M, Mall MA, Schultz C (2019) Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry. ACS Central Science, DOI: 10.1021/acscentsci.8b00933

Ernst AS*, Böhler LI*, Hagenston AM, Hoffmann A, Heiland S, Sticht C, Bendszus M, Hecker M, Bading H, Marti HH, Korff T, Kunze R (*equal contribution) (2019) EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke. Acta Neuropathol Commun, 7, 1, 15

Ivey Williams MP, Rigon M, Straka T, Hörner SJ, Thiel M, Gretz N, Hafner M, Reischl M, Rudolf R (2019) A Novel Optical Tissue Clearing Protocol for Mouse Skeletal Muscle to Visualize Endplates in Their Tissue Context. Front Cell Neurosci, doi.org/10.3389/fncel.2019.00049

Hafner A*, Kolbe U*, Freund I, Castiglia V, Kovarik P, Poth T, Herster F, Weigand MA, Weber ANR, Dalpke AH, Eigenbrod T (*equal contribution) (2019) Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo. Front Immunol, doi: 10.3389/fimmu.2019.00198

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