Ruprecht-Karls-Universität Heidelberg
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Publications by HBIGS PhD students:

Publications in 2020

Loerracher A-K, Braunbeck T (2020) Inducibility of cytochrome P450-mediated 7-methoxycoumarin-O-demethylase activity in zebrafish (Danio rerio) embryos. Aquatic Toxicol, 225, 105540, doi:

Bajak K, Leiss K, Clayton C, Erben E (2020) A potential role for a novel ZC3H5 complex in regulating mRNA translation in Trypanosoma brucei. J Biol Chem, doi: 10.1074/jbc.RA120.014346, doi:

Altamura S, Marques O, Colucci S, Mertens C, Alikhanyan K, Muckenthaler MU (2020) Regulation of iron homeostasis: Lessons from mouse models. Mol Aspects Med, doi.org/10.1016/j.mam.2020.100872, doi:

Radoeva T, Albrecht C, Piepers M, de Vries S, Weijers D (2020) Suspensor-derived somatic embryogenesis in Arabidopsis. Development, doi: 10.1242/dev.188912, doi:

Brito DVC, Gulmez Karaca K, Kupke J, Mudlaff F, Zeuch B, Gomes R, Lopes LV, Oliveira AMM (2020) Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice. Neurobiol Aging, doi: 10.1016/j.neurobiolaging.2020.06.021, doi:

Romano E, Baumschlager A, Akmeriç EB, Palanisamy N, Houmani M, Schmidt G, Öztürk MA, Ernst L, Khammash M, Di Ventura B (2020) An inducible AraC that responds to blue light instead of arabinose. bioRxiv, doi: https://doi.org/10.1101/2020.07.14.202911, doi:

Weigand T, Colbatzky F, Pfeffer T, Garbade SF, Klingbeil K, Colbatzky F, Becker M, Zemva J, Bulkescher R, Schürfeld R, Thiel C, Volk N, Reuss D, Hoffmann GF, Freichel M, Hecker M, Poth T, Fleming T, Poschet G, Schmitt CP, Peters V (2020) A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice. Int J Mol Sci, doi: 10.3390/ijms21144887, doi:

Figlia G, Willnow P, Teleman A (2020) Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins Dev Cell, 54, 2, 156-170, doi:

Kühl N, Graf D, Bock J, Behnam MAM, Leuthold MM, Klein CD (2020) A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays. J Med Chem, doi: 10.1021/acs.jmedchem.0c00413, doi:

Malsam J, Bärfuss S, Trimbuch T, Zarebidaki F, Sonnen AF, Wild K, Scheutzow A, Rohland L, Mayer MP, Sinning I, Briggs JAG, Rosenmund C, Söllner TH (2020) Complexin Suppresses Spontaneous Exocytosis by Capturing the Membrane-Proximal Regions of VAMP2 and SNAP25. Cell Rep, doi: 10.1016/j.celrep.2020.107926, doi:

Léger P, Nachman E, Richter K, Tamietti C, Koch J, Burk R, Kummer S, Xin Q, Stanifer M, Bouloy M, Boulant S, Kräusslich HG, Montagutelli X, Flamand M, Nussbaum-Krammer C, Lozach PY (2020) NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice. Nat Commun, doi: 10.1038/s41467-020-17101-y, doi:

Dao Thi VL, Herbst K, Boerner K, Meurer M, Kremer LP, Kirrmaier D, Freistaedter A, Papagiannidis D, Galmozzi C, Stanifer ML, Boulant S, Klein S, Chlanda P, Khalid D, Miranda IB, Schnitzler P, Kräusslich HG, Knop M, Anders S (2020) A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples. Sci Transl Med, doi: 10.1126/scitranslmed.abc7075, doi:

Mutlu A, Kaspar C, Becker N, Bischofs IB (2020) A spore quality-quantity tradeoff favors diverse sporulation strategies in Bacillus subtilis. ISME J, doi: 10.1038/s41396-020-0721-4, doi:

Lysyk L, Brassard R, Arutyunova E, Siebert V, Jiang Z, Takyi E, Morrison M, Young HS, Lemberg MK, O’Donoghue AJ, Lemieux MJ (2020) Insights into the catalytic properties of the mitochondrial rhomboid protease PARL. bioRxiv, doi:

Grassl N, Bunse L, Beutel T, Klockziem M, Gass A, Platten M, Eisele P (2020) Nivolumab for Treatment of Progressive Multifocal Leukoencephalopathy in Sézary Syndrome. Eur J Neurol, doi: 10.1111/ene.14433, doi:

Fueller J, Herbst K, Meurer M, Gubicza K, Kurtulmus B, Knopf JD, Kirrmaier D, Buchmuller BC, Pereira G, Lemberg MK, Knop M (2020) CRISPR-Cas12a-assisted PCR tagging of mammalian genes. J Cell Biol, doi: 10.1083/jcb.201910210, doi:

Kmiecik SW, Breton L, Mayer MP (2020) Feedback regulation of heat shock factor 1 (Hsf1) activity by Hsp70-mediated trimer unzipping and dissociation from DNA. EMBO J, doi: 10.15252/embj.2019104096, doi:

Nascimento LMD, Terrao M, Marucha KK, Liu B, Egler F, Clayton C (2020) The RNA-associated MKT1 and MKT1L form alternative PBP1-containing complexes in Trypanosoma brucei. J Biol Chem, doi: 10.1074/jbc.RA120.013306, doi:

Stanifer ML, Kee C, Cortese M, Zumaran CM, Triana S, Mukenhirn M, Kraeusslich HG, Alexandrov T, Bartenschlager R, Boulant S (2020) Critical role of type III interferon in controlling SARS-CoV-2 infection in human intestinal epithelial cells. Cell Rep, doi: 10.1016/j.celrep.2020.107863, doi:

Wei Q, Holle A, Li J, Posa F, Biagioni F, Croci O, Benk AS; Young J, Noureddine F, Deng J, ZhangM, InmanGJ, Spatz JP, Campaner S, Cavalcanti‐Adam EA (2020) BMP‐2 Signaling and Mechanotransduction Synergize to Drive Osteogenic Differentiation via YAP/TAZ. Adv Sci, doi 10.1002/advs.201902931, doi:

Bohlen J, Fenzl K, Kramer G, Bukau B, Teleman AA (2020) Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells. Mol Cell, doi: 10.1016/j.molcel.2020.06.005, doi:

Souto-Carneiro MM, Klika KD, Abreu MT, Meyer AP, Saffrich R, Sandhoff R, Jennemann R, Kraus FV, Tykocinski L, Eckstein V, Carvalho L, Kriegsmann M, Giese T, Lorenz HM, Carvalho RA (2020) Proinflammatory profile of autoimmune CD8+ T cells relies on increased LDHA activity and aerobic glycolysis. Arthritis Rheumatol, doi: 10.1002/art.41420, doi:

Anna D. Koromyslova, Jessica M. Devant, Turgay Kilic, Charles D. Sabin, Virginie Malak, Grant S. Hansman (2020) Nanobody-Mediated Neutralization Reveals an Achilles Heel for Norovirus. J Virol 2020 Jun 16;94(13)., doi:

Eismann B, Krieger TG, Beneke J, Bulkescher R, Adam L, Erfle H, Herrmann C, Eils R, Conrad C (2020) Automated 3D light-sheet screening with high spatiotemporal resolution reveals mitotic phenotypes. J Cell Sci, doi: 10.1242/jcs.245043, doi:

Felix I, Lomada SK, Barth H, Wieland T (2020) Bacillus anthracis' PA63 Delivers the Tumor Metastasis Suppressor Protein NDPK-A/NME1 into Breast Cancer Cells. Int J Mol Sci, doi: 10.3390/ijms21093295, doi:

Sloan J, Hakenjos JP, Gebert M, Ermakova O, Gumiero A, Stier G, Wild K, Sinning I, Lohmann JU (2020) Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL. Nat Commun, doi: 10.1038/s41467-020-16024-y, doi:

Boumezbeur AH, Bruer M, Stoecklin G, Mack M (2020) Rational engineering of transcriptional riboswitches leads to enhanced metabolite levels in Bacillus subtilis. Metab Eng, doi: 10.1016/j.ymben.2020.05.002, doi:

Rafiee MR, Sigismondo G, Kalxdorf M, Förster L, Brügger B, Béthune J, Krijgsveld J (2020) Protease-resistant streptavidin for interaction proteomics. Mol Syst Biol, doi: 10.15252/msb.20199370, doi:

Denzer L, Schroten H, Schwerk C (2020) From Gene to Protein—How Bacterial Virulence Factors Manipulate Host Gene Expression During Infection. Int J Mol Sci, 21, 3730, doi:

Tittelmeier J, Sandhof CA, Ries HM, Druffel-Augustin S, Mogk A, Bukau B, Nussbaum-Krammer C (2020) The HSP110/HSP70 disaggregation system generates spreading-competent toxic α-synuclein species. EMBO J, doi: 10.15252/embj.2019103954, doi:

Armbruster L, Linster E, Boyer JB, Brünje A, Eirich J, Stephan I, Bienvenut WV, Weidenhausen J, Meinnel T, Hell R, Sinning I, Finkemeier I, Giglione C, Wirtz M (2020) NAA50 is an enzymatically active Nα-acetyltransferase that is crucial for development and regulation of stress responses. Plant Physiol, doi: 10.1104/pp.20.00222, doi:

Fuchs M, Lohmann JU (2020) Aiming for the top: non-cell autonomous control of shoot stem cells in Arabidopsis. J Plant Res, doi: 10.1007/s10265-020-01174-3, doi:

Yücel SS, Lemberg MK (2020) Signal Peptide Peptidase-Type Proteases: Versatile Regulators with Functions Ranging from Limited Proteolysis to Protein Degradation. J Mol Biol, doi: 10.1016/j.jmb.2020.05.014, doi:

Chatterjee A*, Eshwaran R*, Huang H, Zhao D, Schmidt M, Wieland T, Feng Y (*equal contribution) (2020) Role of the Ang2-Tie2 Axis in Vascular Damage Driven by High Glucose or Nucleoside Diphosphate Kinase B Deficiency. Int J Mol Sci, doi: 10.3390/ijms21103713, doi:

Palanisamy N, Öztürk MA, Akmeriç EB, Di Ventura B (2020) C-terminal eYFP fusion impairs Escherichia coli MinE function. Open Biol, doi: 10.1098/rsob.200010, doi:

Bajak K, Clayton C (2020) Polysome Profiling and Metabolic Labeling Methods to Measure Translation in Trypanosoma brucei. Methods Mol Biol, doi: 10.1007/978-1-0716-0294-2_7, doi:

Corless S, Höcker S, Erhardt S (2020) Centromeric RNA and its function at and beyond centromeric chromatin. J Mol Biol, doi: 10.1016/j.jmb.2020.03.027, doi:

Remo A, Li X, Schiebel E, Pancione M (2020) The Centrosome Linker and Its Role in Cancer and Genetic Disorders. Trends Mol Med, doi: 10.1016/j.molmed.2020.01.011, doi:

Montgomery ST, Frey DL, Mall MA, Stick SM, Kicic A (2020) Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis. Front Immunol, DOI 10.3389/fimmu.2020.00596, doi:

Segin S, Berlin M, Richter C, Flockerzi RMV, Worley P, Freichel M, Londoño JEC (2020) Cardiomyocyte-Specific Deletion of Orai1 Reveals Its Protective Role in Angiotensin-II-Induced Pathological Cardiac Remodeling
Cells, doi: 10.3390/cells9051092, doi:

Knopf JD, Lemberg MK (2020) Derlins with scissors: primordial ERAD in bacteria. EMBO J, doi: 10.15252/embj.2020105012, doi:

Drainas AP, Lambuta RA, Ivanova I, Serçin Ö, Sarropoulos I, Smith ML, Efthymiopoulos T, Raeder B, Stütz AM, Waszak SM, Mardin BR, Korbel JO (2020) Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells. Cell Reports, doi: 10.1016/j.celrep.2020.03.029, doi:

Fröhlich B, Yang Y, Thoma J, Czajor J, Lansche C, Sanchez C, Lanzer M, Cloetens P, Tanaka M (2020) Nanofocused Scanning X-ray Fluorescence Microscopy Revealing an Effect of Heterozygous Hemoglobin S and C on Biochemical Activities in Plasmodium falciparum-Infected Erythrocytes. Anal Chem, doi: 10.1021/acs.analchem.9b05111, doi:

Gruber A, Müller R, Wagner A, Colucci S, Spasić MV, Leopold K (2020) Total reflection X-ray fluorescence spectrometry for trace determination of iron and some additional elements in biological samples. Anal Bioanal Chem, doi: 10.1007/s00216-020-02614-8, doi:

Hirth M, Gandla J, Höper C, Gaida MM, Agarwal N, Simonetti M, Demir A, Xie Y, Weiss C, Michalski CW, Hackert T, Ebert MP, Kuner R (2020) CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in Patients. Gastroenterology, doi: 10.1053/j.gastro.2020.04.037, doi:

Loerracher A-K , Grethlein M, Braunbeck T (2020) In Vivo Fluorescence-Based Characterization of Cytochrome P450 Activity During Embryonic Development of Zebrafish (Danio Rerio). Ecotoxicol Environ Saf, doi: 10.1016/j.ecoenv.2020.110330, doi:

Zindler F, Tisler S, Loerracher AK, Zwiener C, Braunbeck T (2020) Norfluoxetine Is the Only Metabolite of Fluoxetine in Zebrafish ( Danio rerio) Embryos That Accumulates at Environmentally Relevant Exposure Scenarios. Environ Sci Technol, doi: 10.1021/acs.est.9b07618, doi:

Ritter C, Newrly A, Schifferdecker S, Roggenbach I, Müller B, Rohr K (2020) Optimizing Particle Detection by Colocalization Analysis in Multi-Channel Fluorescence Microscopy Images. 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), doi: 10.1109/ISBI45749.2020.9098659, doi:

Hagner M*, Frey DL*, Guerra M*, Dittrich AS, Halls VS, Wege S, Herth FJF, Schultz C, Mall MA (*equal contribution) (2020) New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry. Eur Respir J, DOI: 10.1183/13993003.02355-2019, doi:

Seleit A, Gross K, Onistschenko J, Woelk M, Autorino C, Centanin L (2020) Development and Regeneration Dynamics of the Medaka Notochord. Dev Biol, doi: 10.1016/j.ydbio.2020.03.001, doi:

Dreher SI, Fischer J, Walker T, Diederichs S, Richter W (2020) Significance of MEF2C and RUNX3 Regulation for Endochondral Differentiation of Human Mesenchymal Progenitor Cells. Front Cell Dev Biol, doi: 10.3389/fcell.2020.00081, doi:

Zhang Y, Valentín Gesé G, Conz C, Lapouge K, Kopp J, Wölfle T, Rospert S, Sinning I (2020) The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat Commun, doi: 10.1038/s41467-020-15313-w, doi:

Legrand C, Saleppico R, Sticht J, Lolicato F, Müller HM, Wegehingel S, Dimou E, Steringer JP, Ewers H, Vattulainen I, Freund C, Nickel W (2020) The Na,K-ATPase acts upstream of phosphoinositide PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2. Commun Biol, doi: 10.1038/s42003-020-0871-y, doi:

John A, Robador JR, Vidal-Y-Sy S, Houdek P, Wladykowski E, Guenes C, Bolenz C, Schneider SW, Bauer AT, Gorzelanny C. (2020) Urothelial carcinoma of the bladder induces endothelial cell activation and hypercoagulation. Mol Cancer Res. DOI: 10.1158/1541-7786.MCR-19-1041, doi:

Eritano AS, Bromley CL, Bolea Albero A, Schütz L, Wen FL, Takeda M, Fukaya T, Sami MM, Shibata T, Lemke S, Wang YC (2020) Tissue-Scale Mechanical Coupling Reduces Morphogenetic Noise to Ensure Precision during Epithelial Folding. Dev Cell, doi: 10.1016/j.devcel.2020.02.012, doi:

Knopf JD, Landscheidt N, Pegg CL, Schulz BL, Kühnle N, Chao CW, Huck S, Lemberg MK (2020) Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation. J Cell Sci, doi: 10.1242/jcs.243790, doi:

Bajak K, Leiss K, Clayton CE, Erben​ E (2020) The endoplasmic reticulum-associated mRNA-binding proteins ERBP1 and ERBP2 interact in bloodstream-form Trypanosoma brucei. PeerJ, doi: 10.7717/peerj.8388, doi:

Atorino ES, Hata S, Funaya C, Neuner A, Schiebel E (2020) CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion. Nat Commun, doi: 10.1038/s41467-020-14767-2, doi:

Wild K, Aleksić M, Lapouge K, Juaire KD, Flemming D, Pfeffer S, Sinning I (2020) MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments. Nat Commun, doi: 10.1038/s41467-020-14603-7, doi:

Staufer O, Schröter M, Platzman I, Spatz JP (2020) Bottom-Up Assembly of Functional Intracellular Synthetic Organelles by Droplet-Based Microfluidics. Small, doi: 10.1002/smll.201906424, doi:

Tangudu NK, Yilmaz D, Wörle K, Gruber A, Colucci S, Leopold K, Muckenthaler MU, Vujic Spasic M (2020) Macrophage-HFE Controls Iron Metabolism And Immune Responses In Aged Mice. Haematologica, doi: 10.3324/haematol.2019.235630, doi:

Pagani A*, Pettinato M*, Colucci S*, Dulja A, Rauner M, Nai A, Camaschella C, Altamura S, Muckenthaler MU, Silvestri L (*equal contribution) (2020) Hemochromatosis Proteins Are Dispensable For The Acute Hepcidin Response To BMP2. Haematologica, doi: 10.3324/haematol.2019.241984, doi:

Port F, Strein C, Stricker M, Rauscher B, Heigwer F, Zhou J, Beyersdörffer C, Frei J, Hess A, Kern K, Lange L, Langner N, Malamud R, Pavlovic B, Rädecke K, Schmitt L, Voos L, Valentini E, Boutros M (2020) A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila. Elife, doi: 10.7554/eLife.53865, doi:

Siméon S, Brotzmann K, Fisher C, Gardner I, Silvester S, Maclennan R, Walker P, Braunbeck T, Bois FY (2020) Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs. Reprod Toxicol, doi: 10.1016/j.reprotox.2020.02.010, doi:

Tizian C, Lahmann A, Hölsken O, Cosovanu C, Kofoed-Branzk M, Heinrich F, Mashreghi MF, Kruglov A, Diefenbach A, Neumann C (2020) c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells. Elife, doi: 10.7554/eLife.52549, doi:

Granados K, Hüser L, Federico A, Sachindra S, Wolff G, Hielscher T, Novak D, Madrigal-Gamboa V, Sun Q, Vierthaler M, Larribère L, Umansky V, Utikal J (2020) T-type calcium channel inhibition restores sensitivity to MAPK inhibitors in de-differentiated and adaptive melanoma cells. Br J Cancer, doi: 10.1038/s41416-020-0751-8, doi:

Münsterberg J, Loreth D, Brylka L, Werner S, Karbanova J, Gandrass M, Schneegans S, Besler K, Hamester F, Robador JR, Bauer AT, Werner Schneider S, Wrage M, Lamszus K, Matschke J, ...Maire C, Wikman H (2020) ALCAM contributes to brain metastasis formation in non-small-cell lung cancer through interaction with the vascular endothelium. Neuro Oncol, doi: 10.1093/neuonc/noaa028, doi:

Buljubasic F, El-Battrawy I, Lan H, Lomada SK, Chatterjee A, Zhao Z, Li X, Zhong R, Xu Q, Huang M, Liao Z, Lang S, Cyganek L, Zhou X, Wieland T, Borggrefe M, Akin I (2020) Nucleoside Diphosphate Kinase B Contributes to Arrhythmogenesis in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with Arrhythmogenic Right Ventricular Cardiomyopathy. J Clin Med, doi: 10.3390/jcm9020486, doi:

Gierten J, Pylatiuk C, Hammouda OT, Schock C, Stegmaier J, Wittbrodt J, Gehrig J, Loosli F (2020) Automated high-throughput heartbeat quantification in medaka and zebrafish embryos under physiological conditions. Sci Rep, doi: 10.1038/s41598-020-58563-w, doi:

Farrants H, Tarnawski M, Müller TG, Otsuka S, Hiblot J, Koch B, Kueblbeck M, Kräusslich HG, Ellenberg J, Johnsson K (2020) Chemogenetic Control of Nanobodies. Nat Methods, doi: 10.1038/s41592-020-0746-7, doi:

Börner K, Kienle E, Huang LY, Weinmann J, Sacher A, Bayer P, Stüllein C, Fakhiri J, Zimmermann L, Westhaus A, Beneke J, Beil N, Wiedtke E, Schmelas C, Miltner D, Rau A, Erfle H, Kräusslich HG, Müller M, Agbandje-McKenna M, Grimm D (2020) Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening. Mol Ther, doi: 10.1016/j.ymthe.2020.02.009, doi:

Nowrouzi A, Sertorio MG, Akbarpour M, Knoll M, Krunic D, Kuhar M, Schwager C, Brons S, Debus J, Wells SI, Wells JM, Abdollahi A (2020) Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids. Cancers (Basel), doi: 10.3390/cancers12020469, doi:

Brito DVC, Kupke J, Gulmez Karaca K, Zeuch B, Oliveira AMM (2020) Mimicking Age-Associated Gadd45γ Dysregulation Results in Memory Impairments in Young Adult Mice. J Neurosci, doi: 10.1523/JNEUROSCI.1621-19.2019, doi:

Brito DVC, Kupke J, Gulmez Karaca K, Zeuch B, Oliveira AMM (2020) Mimicking Age-Associated Gadd45γ Dysregulation Results in Memory Impairments in Young Adult Mice. J Neurosci, doi: 10.1523/JNEUROSCI.1621-19.2019, doi:

Aslan K, Turco V, Blobner J, Sonner JK, Liuzzi AR, Núñez NG, De Feo D, Kickingereder P, Fischer M, Green E, Sadik A, Friedrich M, Sanghvi K, Kilian M, Cichon F, Wolf L, Jähne K, von Landenberg A, Bunse L, ...Wick W, Becher B, Platten M (2020) Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas. Nat Commun, doi: 10.1038/s41467-020-14642-0, doi: