Ruprecht-Karls-Universität Heidelberg
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Publications by HBIGS PhD students:

Publications in 2014

Haslinger K, Maximowitsch E, Brieke C, Koch A, Cryle MJ (2014) Cytochrome P450 OxyBtei catalyzes the first phenolic coupling step in teicoplanin biosynthesis. Chembiochem, 15, 18, 2719-28

Avci D, Fuchs S, Schrul B, Fukumori A, Breker M, Frumkin I, Chen CY, Biniossek ML, Kremmer E, Schilling O, Steiner H, Schuldiner M, Lemberg MK (2014) The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance. Mol Cell, 56, 5, 630-40

Huber F, Meurer M, Bunina D, Kats I, Maeder CI, Stefl M, Mongis C, Knop M (2014) PCR Duplication: A One-Step Cloning-Free Method to Generate Duplicated Chromosomal Loci and Interference-Free Expression Reporters in Yeast. PLoS One, 9, 12, e114590

Radestock B, Burk R, Müller B, Kräusslich HG (2014) Re-visiting the functional Relevance of the highly conserved Serine 40 Residue within HIV-1 p6Gag. Retrovirology, 11, 114

Gnanasundram SV, Koš M (2014) Fast protein depletion system utilizing tetracycline repressible promoter and N-end rule in yeast. Mol Biol Cell, 26, 4, 762-8

Zacherl S, La Venuta G, Müller H, Wegehingel S, Dimou E, Sehr P, Lewis JD, Erfle H, Pepperkok R, Nickel W (2014) A Direct Role for ATP1A1 in Unconventional Secretion of Fibroblast Growth Factor 2. J Biol Chem, pii: jbc.M114.590067

Lin T, Neuner A, Schiebel E (2014) Targeting of γ-tubulin complexes to microtubule organizing centers: conservation and divergence. Trends Cell Biol, pii: S0962-8924(14)00212-8, doi: 10.1016/j.tcb.2014.12.002

Hödebeck M, Scherer C, Wagner AH, Hecker M, Korff T (2014) TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells. Front Physiol, 5, 467

Fernandes P, Frank R, Lewis MD, Mueller AK (2014) Plasmodium attenuation: connecting the dots between early immune responses and malaria disease severity. Front Microbiol, 5, 658

Birke H, De Kok LJ, Wirtz M, Hell R (2014) The role of compartment-specific cysteine synthesis for sulfur homeostasis during H2S exposure in Arabidopsis. Plant Cell Physiol, pii: pcu166.

Sobotta MC, Liou W, Stöcker S, Talwar D, Oehler M, Ruppert T, Scharf AN, Dick TP (2014) Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nat Chem Biol, doi: 10.1038/nchembio.1695

Lee JY, Acosta EG, Stoeck IK, Long G, Hiet MS, Mueller B, Fackler OT, Kallis S, Bartenschlager R (2014) Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins. J Virol, 88, 21, 12422-37

Rošić S, Köhler F, Erhardt S (2014) Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division. J Cell Biol, pii: jcb.201404097

Bellanca S, Summers RL, Meyrath M, Dave A, Nash MN, Dittmer M, Sanchez CP, Stein WD, Martin RE, Lanzer M (2014) Multiple drugs compete for transport via the P. falciparum chloroquine resistance transporter at distinct but interdependent sites. J Biol Chem, doi: 10.1074/jbc.M114.614206 jbc.M114.614206.

Caì Y, Yú SQ, Postnikova EN, Mazur S, Bernbaum JG, Burk R, Zhāng T, Radoshitzky SR, Müller MA, Jordan I, Bollinger L, Hensley LE, Jahrling PB, Kuhn JH (2014) CD26/DPP4 Cell-Surface Expression in Bat Cells Correlates with Bat Cell Susceptibility to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Evolution of Persistent Infection. PLoS One, 9, 11, e112060

Meitinger F, Khmelinskii A, Morlot S, Kurtulmus B, Palani S, Andres-Pons A, Hub B, Knop M, Charvin G, Pereira G (2014) A memory system of negative polarity cues prevents replicative aging. Cell, 159, 5, 1056-69

Gutierrez-Triana J, Herget U, Lichtner P, Castillo-Ramírez LA, Ryu S (2014) A vertebrate-conserved cis -regulatory module for targeted expression in the main hypothalamic regulatory region for the stress response. BMC Dev Biol, 14, 1, 41

Zeymer C, Fischer S, Reinstein J (2014) trans-Acting Arginine Residues in the AAA+ Chaperone ClpB Allosterically Regulate the Activity through Inter- and Intradomain Communication. J Biol Chem, 289, 47, 32965-76

You L, Wu J, Feng Y, Fu Y, Guo Y, Long L, Zhang H, Luan Y, Tian P, Chen L, Huang G, Huang S, Li Y, Li J, Chen C, Zhang Y, Chen S, Xu A (2014) APASdb: a database describing alternative poly(A) sites and selection of heterogeneous cleavage sites downstream of poly(A) signals. Nucleic Acids Res, doi: 10.1093/nar/gku1076

Gutierrez-Triana JA, Herget U, Lichtner P, Castillo-Ramírez LA, Ryu S. (2014) A vertebrate-conserved cis-regulatory module for targeted expression in the main hypothalamic regulatory region for the stress response. BMC Dev Biol;14:41

Irving WL*, Rupp D*, McClure CP, Than LM, Titman A, Ball JK, Steinmann E, Bartenschlager R, Pietschmann T, Brown RJ (*equal contribution) (2014) Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region. Antiviral Res, 110, 52-9

Öz S, Raddatz G, Rius M, Blagitko-Dorfs N, Lübbert M, Maercker C, Lyko F (2014) Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells. Nucleic Acids Res, 42, 19, e152

Stein S, Oosterveer MH, Mataki C, Xu P, Lemos V, Havinga R, Dittner C, Ryu D, Menzies KJ, Wang X, Perino A, Houten SM , Melchior F, Schoonjans K (2014) SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport. Cell Metabolism, DOI: 10.1016/j.cmet.2014.07.023

Preuss SJ, Trivedi CA, vom Berg-Maurer, CM Ryu S, Bollmann JH (2014) Classification of Object Size in Retinotectal Microcircuits. Current Biology, 24, 1-10

Korzelius J, Naumann SK, Loza-Coll MA, Chan JS, Dutta D, Oberheim J, Gläßer C, Southall TD, Brand AH, Jones DL, Edgar BA (2014) Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells. EMBO J, pii: e201489072

Agircan FG, Schiebel E (2014) Sensors at Centrosomes Reveal Determinants of Local Separase Activity. PLoS Genet, 10, 10, e1004672

Karl I, Jossberger-Werner M, Schmidt N, Horn S, Goebeler M, Leverkus M, Wajant H, Giner T (2014) TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis. Cell Death Dis, 5, e1444. doi: 10.1038/cddis.2014.404.

Lauriola M, Enuka Y, Zeisel A, D'Uva G, Roth L, Sharon-Sevilla M, Lindzen M, Sharma K, Nevo N, Feldman M, Carvalho S, Cohen-Dvashi H, Kedmi M, Ben-Chetrit N, Chen A, Solmi R, Wiemann S, Schmitt F, Domany E, Yarden Y (2014) Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment. Nat Commun, 3, 5, 5073

Haller C, Müller B, Fritz JV, Lamas Murua M, Stolp B, Pujol F, Keppler OT, Fackler OT (2014) HIV-1 Nef and Vpu are Functionally Redundant Broad-Spectrum Modulators of Cell Surface Receptors Including Tetraspanins. J Virol, pii: JVI.02333-14

Hohmann N, Schmickl R, Chiang T-Y, Lucanova M, Kolar F, Marhold K and Koch MA (2014) Taming the wild: resolving the gene pools of non-model Arabidopsis lineages. BMC Evol Biol, 14, 1, 224

Daum G, Medzihradszky A, Suzaki T, Lohmann JU (2014) A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis. Proc Natl Acad Sci U S A, 111, 40, 14619-24

Stangl M, Unger S, Keller S, Schneider D (2014) Sequence-specific dimerization of a transmembrane helix in amphipol a8-35. PLoS One, 9, 10, e110970

Leder V, Lummer M, Tegeler K, Humpert F, Lewinski M, Schüttpelz M, Staiger D. (2014) Mutational definition of binding requirements of an hnRNP-like protein in Arabidopsis using fluorescence correlation spectroscopy. Biochem Biophys Res Commun, 453, 1, 69-74

Vilches-Barro A, Maizel A (2014) Talking through walls: mechanisms of lateral root emergence in Arabidopsis thaliana. Curr Opin Plant Biol, 23C, 31-38

Winterhalter PR, Ruppert T, Strahl S (2014) Identification of Mammalian O-Mannosylated Glycopeptides Glycoscience: Biology and Medicine, 1081-1089

Bandapalli OR, Schuessele S, Kunz JB, Rausch T, Stütz AM, Tal N, Geron I, Gershman N, Izraeli S, Eilers J, Vaezipour N, Kirschner-Schwabe R, Hof J, von Stackelberg A, Schrappe M, Stanulla M, Zimmermann M, Koehler R, Avigad S, Handgretinger R, Frisman (2014) The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse. Haematologica, 99, 10, e188-92

Wiestler B, Capper D, Sill M, Jones DT, Hovestadt V, Sturm D, Koelsche C, Bertoni A, Schweizer L, Korshunov A, Weiß EK, Schliesser MG, Radbruch A, Herold-Mende C, Roth P, Unterberg A, Hartmann C, Pietsch T, Reifenberger G, Lichter P, Radlwimmer B, Pl (2014) Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma. Acta Neuropathol, 128, 4, 561-71

Appari M, Babu KR, Kaczorowski A, Gross W, Herr I (2014) Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition. Int J Oncol, 45, 4, 1391-400

Obr M, Hadravova R, Dolezal M, Krizova I, Papouskova V, Zidek L, Hrabal R, Ruml T, Rumlova M (2014) Stabilization of the β-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity. Retrovirology, 11, 94

Weinreuter M, Kreusser MM, Beckendorf J, Schreiter FC, Leuschner F, Lehmann LH, Hofmann KP, Rostosky JS, Diemert N, Xu C, Volz HC, Jungmann A, Nickel A, Sticht C, Gretz N, Maack C, Schneider MD, Gröne HJ, Müller OJ, Katus HA, Backs J. (2014) CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury. EMBO Mol Med, 10, 1231-45

Agircan FG, Schiebel E, Mardin BR (2014) Separate to operate: control of centrosome positioning and separation. Philos Trans R Soc Lond B Biol Sci, 369, 1650, pii: 20130461

Kumar R (2014) Role of MicroRNAs in Biotic and Abiotic Stress Responses in Crop Plants. Appl Biochem Biotechnol, 174, 1, 93-115

Seyedmohammad S, Born D, Venter H (2014) Expression, purification and functional reconstitution of FeoB, the ferrous iron transporter from Pseudomonas aeruginosa. Protein Expr Purif, 101, 138-45

Bernardo-Faura M, Massen S, Falk CS, Brady NR, Eils R (2014) Data-derived modeling characterizes plasticity of MAPK signaling in melanoma. PLoS Comput Biol, 10, 9, e1003795

Klermund J, Bender K, Luke B (2014) High Nutrient Levels and TORC1 Activity Reduce Cell Viability following Prolonged Telomere Dysfunction and Cell Cycle Arrest. Cell Rep, pii: S2211-1247(14)00729-3.

Senis E*, Fatouros C*, Grosse S*, Wiedtke E, Niopek D, Mueller AK, Börner K, Grimm D (*equal contribution) (2014) CRISPR/Cas9-mediated genome engineering: An adeno-associated viral (AAV) vector toolbox. Biotechnol J, doi: 10.1002/biot.201400046

Simons MN, Saha R, Amiour N, Kumar A, Guillard L, Clément G, Miquel M, Li Z, Mouille G, Hirel B, Maranas CD (2014) Assessing the Metabolic Impact of Nitrogen Availability using a Compartmentalized Maize Leaf Genome-Scale Model. Plant Physiol, pii: pp.114.245787

Chen CY*, Malchus NS*, Hehn B, Stelzer W, Avci D, Langosch D, Lemberg MK (*equal contribution) (2014) Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u. EMBO J, pii: e201488208

Kempf G, Wild K, Sinning I (2014) Structure of the complete bacterial SRP Alu domain. Nucleic Acids Res, pii: gku883

Geserick P, Wang J, Feoktistova M, Leverkus M (2014) The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin. Cell Death Dis, 5, e1412. doi: 10.1038/cddis.2014.379

Hentzschel F, Hammerschmidt-Kamper C, Börner K, Heiss K, Knapp B, Sattler JM, Kaderali L, Castoldi M, Bindman JG, Malato Y, Willenbring H, Mueller AK, Grimm D (2014) AAV8-Mediated In Vivo Overexpression of miR-155 Enhances the Protective Capacity of Genetically Attenuated Malarial Parasites. Mol Ther, doi: 10.1038/mt.2014.172

Eckert ES, Reckmann I, Hellwig A, Röhling S, El-Battari A, Wieland FT, Popoff V (2014) Golgi Phosphoprotein 3 Triggers Signal-mediated Incorporation of Glycosyltransferases into Coatomer-coated (COPI) Vesicles. J Biol Chem,289, 45, 31319-29

Forieri I, Hell R (2014) Micronutrient Use Efficiency – Cell Biology of Iron and Its Metabolic Interactions in Plants. Plant Ecophysiology,10, 133-152

Thomann S, Longerich T, Bazhin AV, Mier W, Schemmer P, Ryschich E (2014) Selective targeting of liver cancer with the endothelial marker CD146. Oncotarget, 5, 18, 8614-24

Li SB, Du D, Hasan MT, Köhr G (2014) D4 Receptor Activation Differentially Modulates Hippocampal Basal and Apical Dendritic Synapses in Freely Moving Mice. Cereb Cortex, doi: 10.1093/cercor/bhu229

Gerola S, Nittka S, Kähler G, Tao S, Brenner H, Binelli G, Eils R, Brors B, Neumaier M (2014) Genetic variants in apoptosis-related genes associated with colorectal hyperplasia. Genes Chromosomes Cancer, 53, 9, 769-78

Medina MW, Bauzon F, Naidoo D, Theusch E, Stevens K, Schilde J, Schubert C, Mangravite LM, Rudel LL, Temel RE, Runz H, Krauss RM (2014) Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism. Arterioscler Thromb Vasc Biol, 34, 9, 1917-23

Abu El Maaty MA, Hanafi RS, El-Badawy S, Gad MZ (2014) Interplay of vitamin D and nitric oxide in post-menopausal knee osteoarthritis. Aging Clin Exp Res, 26, 4, 363-8

Gladilin E, González P, Eils R (2014) Dissecting the contribution of actin and vimentin intermediate filaments to mechanical phenotype of suspended cells using high-throughput deformability measurements and computational modeling. J Biomech, 47, 11, 2598-605

Müller-Ott K, Erdel F, Matveeva A, Mallm JP, Rademacher A, Hahn M, Bauer C, Zhang Q, Kaltofen S, Schotta G, Höfer T, Rippe K (2014) Specificity, propagation, and memory of pericentric heterochromatin. Mol Syst Biol, 10, 8, 746

Watanabe H, Schmidt HA, Kuhn A, Höger SK, Kocagöz Y, Laumann-Lipp N, Özbek S, Holstein TW (2014) Nodal signalling determines biradial asymmetry in Hydra Nature, doi:10.1038/nature13666

Fadda A, Ryten M, Droll D, Rojas F, Färber V, Haanstra JR, Merce C, Bakker BM, Matthews K, Clayton C (2014) Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels. Mol Microbiol, doi: 10.1111/mmi.12764

Denninger P, Bleckmann A, Lausser A, Vogler F, Ott T, Ehrhardt DW, Frommer WB, Sprunck S, Dresselhaus T, Grossmann G (2014) Male-female communication triggers calcium signatures during fertilization in Arabidopsis. Nat Commun, 5, 4645

Centanin L, Ander JJ, Hoeckendorf B, Lust K, Kellner T, Kraemer I, Urbany C, Hasel E, Harris WA, Simons BD, Wittbrodt J (2014) Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina. Development, 141, 18, 3472-82

Sinn R, Peravali R, Heermann S, Wittbrodt J (2014) Differential responsiveness of distinct retinal domains to Atoh7. Mech Dev, pii: S0925-4773(14)00038-0

Wieland S, Du D, Oswald MJ, Parlato R, Köhr G, Kelsch W (2014) Phasic Dopaminergic Activity Exerts Fast Control of Cholinergic Interneuron Firing via Sequential NMDA, D2, and D1 Receptor Activation. J Neurosci, 34, 35, 11549-59

Engeland CE, Grossardt C, Veinalde R, Bossow S, Lutz D, Kaufmann JK, Shevchenko I, Umansky V, Nettelbeck DM, Weichert W, Jäger D, von Kalle C, Ungerechts G (2014) CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy. Mol Ther, doi: 10.1038/mt.2014.160.

Baertsch MA, Leber MF, Bossow S, Singh M, Engeland CE, Albert J, Grossardt C, Jäger D, von Kalle C, Ungerechts G (2014) MicroRNA-mediated multi-tissue detargeting of oncolytic measles virus. Cancer Gene Ther, doi: 10.1038/cgt.2014.40.

Schilling R, Geserick P, Leverkus M (2014) Characterization of the Ripoptosome and Its Components: Implications for Anti-inflammatory and Cancer Therapy. Methods Enzymol, 545, 83-102

Khodosevich K, Jacobi E, Farrow P, Schulmann A, Rusu A, Zhang L, Sprengel R, Monyer H, von Engelhardt J (2014) Coexpressed auxiliary subunits exhibit distinct modulatory profiles on AMPA receptor function. Neuron, 83, 3, 601-15

Yan J, Liu XH, Han MZ, Wang YM, Sun XL, Yu N, Li T, Su B, Chen ZY (2014) Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease. Neurobiol Aging, doi: 10.1016/j.neurobiolaging.2014.08.005

Haslinger K, Brieke C, Uhlmann S, Sieverling L, Süssmuth RD, Cryle MJ (2014) The structure of a transient complex of a nonribosomal Peptide synthetase and a cytochrome p450 monooxygenase. Angew Chem Int Ed Engl, 53, 32, 8518-22

Wang H, Flannery SM, Dickhöfer S, Huhn S, George J, Kubarenko AV, Lascorz J, Bevier M, Willemsen J, Pichulik T, Schafmayer C, Binder M, Manoury B, Paludan SR, Alarcon-Riquelme M, Bowie AG, Försti A, Weber AN (2014) A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival. J Biol Chem, 289, 33, 23123-31

Patrick Heinrich, Ulrike Diehl, Franziska Förster, Thomas Braunbeck (2014) Improving the in vitro ethoxyresorufin-O-deethylase (EROD) assay with RTL-W1 by metabolic normalization and use of β-naphthoflavone as the reference substance Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 164, 27 – 34

Weitnauer M, Schmidt L, Ng Kuet Leong N, Muenchau S, Lasitschka F, Eckstein V, Hübner S, Tuckermann J, Dalpke AH (2014) Bronchial epithelial cells induce alternatively activated dendritic cells dependent on glucocorticoid receptor signaling. J Immunol, 193, 3, 1475-84

Kapitein N, Mogk A (2014) Type VI Secretion System Helps Find a Niche. Cell Host Microbe, 16, 1, 5-6

Lempp FA, Urban S (2014) Inhibitors of hepatitis B virus attachment and entry. Intervirology, 57, 3-4, 151-157

Berger C, Romero-Brey I, Radujkovic D, Terreux R, Zayas M, Paul D, Harak C, Hoppe S, Gao M, Penin F, Lohmann V, Bartenschlager R (2014) Daclatasvir-like Inhibitors of NS5A Block Early Biogenesis of HCV-induced Membranous Replication Factories, Independent of RNA Replication. Gastroenterology, pii: S0016-5085(14)00915-9

Niopek D, Benzinger D, Roensch J, Dräbing T, Wehler P, Eils R, Di Ventura B (2014) Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells. Nat Commun, 14, 5, 4404

Schleich S, Strassburger K, Janiesch PC, Koledachkina T, Miller KK, Haneke K, Cheng YS, Küchler K, Stoecklin G, Duncan KE, Teleman AA (2014) DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth. Nature, doi: 10.1038/nature13401

Begolo D, Erben E, Clayton C (2014) Drug target identification using a trypanosome over-expression library. Antimicrob Agents Chemother, pii: AAC.03338-14

Bubendorfer S, Koltai M, Rossmann F, Sourjik V, Thormann KM (2014) Secondary bacterial flagellar system improves bacterial spreading by increasing the directional persistence of swimming. Proc Natl Acad Sci U S A, 111, 31, 11485-90

Hofner T, Macher-Goeppinger S, Klein C, Schillert A, Eisen C, Wagner S, Rigo-Watermeier T, Baccelli I, Vogel V, Trumpp A, Sprick MR (2014) Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy. Urol Oncol, 32, 5, 678-86

Engeland CE, Brown NP, Börner K, Schümann M, Krause E, Kaderali L, Müller GA, Kräusslich HG (2014) Proteome analysis of the HIV-1 Gag interactome. Virology, 460-461, 194-206

Hieb AR, Gansen A, Böhm V, Langowski J (2014) The conformational state of the nucleosome entry-exit site modulates TATA box-specific TBP binding. Nucleic Acids Res, 42, 12, 7561-76

Hoffmann J, Symul L, Shostak A, Fischer T, Naef F, Brunner M (2014) Non-circadian expression masking clock-driven weak transcription rhythms in U2OS cells. PLoS One, 9, 7, e102238

Elserafy M.*, Sarić M.*, Neuner A.*, Lin TC., Zhang W., Seybold C., Sivashanmugam L., Schiebel E. *Equal contibution (2014) Molecular Mechanisms that Restrict Yeast Centrosome Duplication to One Event per Cell Cycle. Curr Biol, 24, 1–11

Harak C, Radujkovic D, Taveneau C, Reiss S, Klein R, Bressanelli S, Lohmann V (2014) Mapping of functional domains of the lipid kinase phosphatidylinositol 4-kinase type III alpha involved in enzymatic activity and hepatitis c virus replication. J Virol, doi:10.1128/JVI.01063-14

Graf C, Lee CT, Meier-Andrejszki LE, Nguyen MTN, Mayer MP (2014) Differences in conformational dynamics within the Hsp90 chaperone family reveal mechanistic insights. Front Mol Biosci, doi: 10.3389/fmolb.2014.00004

Hsieh TY, Nillegoda NB, Tyedmers J, Bukau B, Mogk A, Kramer G (2014) Monitoring protein misfolding by site-specific labeling of proteins in vivo. PLoS One, 10, 9, 6

Schott J, Reitter S, Philipp J, Haneke K, Schäfer H, Stoecklin G (2014) Translational Regulation of Specific mRNAs Controls Feedback Inhibition and Survival during Macrophage Activation. PLoS Genet, 10, 6, e1004368

Dikfidan A, Loll B, Zeymer C, Magler I, Clausen T, Meinhart A (2014) RNA Specificity and Regulation of Catalysis in the Eukaryotic Polynucleotide Kinase Clp1. Mol Cell, 54, 6, 975-86

Arnold C, Feldner A, Pfisterer L, Hödebeck M, Troidl K, Genové G, Wieland T, Hecker M, Korff T (2014) RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med, pii: e201403864. doi: 10.15252/emmm.201403864

Kube S, Kapitein N, Zimniak T, Herzog F, Mogk A, Wendler P (2014) Structure of the VipA/B Type VI Secretion Complex Suggests a Contraction-State-Specific Recycling Mechanism. Cell Rep, pii: S2211-1247(14)00428-8. doi: 10.1016/j.celrep.2014.05.034

Bharat TA, Castillo Menendez LR, Hagen WJ, Lux V, Igonet S, Schorb M, Schur FK, Kräusslich HG, Briggs JA (2014) Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly. Proc Natl Acad Sci U S A, 111, 22, 8233-8

Eskova A, Knapp B, Matelska D, Reusing S, Arjonen A, Lisauskas T, Pepperkok R, Russell R, Eils R, Ivaska J, Kaderali L, Erfle H, Starkuviene V (2014) An RNAi screen identifies KIF15 as a novel regulator of the endocytic trafficking of integrin. J Cell Sci, 127, Pt 11, 2433-47

Medyouf H, Mossner M, Jann JC, Nolte F, Raffel S, Herrmann C, Lier A, Eisen C, Nowak V, Zens B, Müdder K, Klein C, Obländer J, Fey S, Vogler J, Fabarius A, Riedl E, Roehl H, Kohlmann A, Staller M, Haferlach C, Müller N, John T, Platzbecker U, Metzger (2014) Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit. Cell Stem Cell, 14, 6, 824-37

Schumacher T*, Bunse L*, Pusch S, Sahm F, Wiestler B, Quandt J, Menn O, Osswald M, Oezen I, Ott M, Keil M, Balß J, Rauschenbach K, Grabowska AK, Vogler I, Diekmann J, Trautwein N, Eichmüller SB,..., Wick W, Platten M (*equal contribution) (2014) A vaccine targeting mutant IDH1 induces antitumour immunity. Nature, 512, 7514, 324-7

Beer R, Herbst K, Ignatiadis N, Kats I, Adlung L, Meyer H, Niopek D, Christiansen T, Georgi F, Kurzawa N, Meichsner J, Rabe S, Riedel A, Sachs J, Schessner J, Schmidt F, Walch P, Niopek K, Heinemann T, Eils R, Di Ventura B (2014) Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange. Mol Biosyst, 10,7, 1709–18

Stamellou E, Fontana J, Wedel J, Ntasis E, Sticht C, Becker A, Pallavi P, Wolf K, Krämer BK, Hafner M, van Son WJ, Yard BA (2014) N-octanoyl dopamine treatment of endothelial cells induces the unfolded protein response and results in hypometabolism and tolerance to hypothermia. PLoS One, 9, 6, e99298

Köthe U, Herrmannsdörfer F, Kats I, Hamprecht FA (2014) SimpleSTORM: a fast, self-calibrating reconstruction algorithm for localization microscopy Histochem Cell Biol, 141, 6, 613–627

Lindner R, Lou X, Reinstein J, Shoeman RL, Hamprecht FA, Winkler A (2014) Hexicon 2: automated processing of hydrogen-deuterium exchange mass spectrometry data with improved deuteration distribution estimation. J Am Soc Mass Spectrom, 25, 6, 1018-28

Kohlmaier A, Fassnacht C, Jin Y, Reuter H, Begum J, Dutta D, Edgar BA (2014) Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine. Oncogene, doi: 10.1038/onc.2014.163

Walstab J, Wohlfarth C, Hovius R, Schmitteckert S, Röth R, Lasitschka F, Wink M, Bönisch H, Niesler B (2014) Natural compounds boldine and menthol are antagonists of human 5-HT3 receptors: implications for treating gastrointestinal disorders. Neurogastroenterol Motil, 26, 6, 810-20

Quadrato G, Elnaggar M Y, Duman C, Sabino A, Forsberg K, Di Giovanni S (2014) Modulation of GABAA Receptor Signaling Increases Neurogenesis and Suppresses Anxiety through NFATc4. J Neurosci, 34, 25, 8630–8645.

Ernst AM, Brügger B (2014) Sphingolipids as modulators of membrane proteins. Biochim Biophys Acta, S1388-1981, 13, 00239-4

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